期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

DNA疫苗免疫途径的研究现状 被引量：1

The current study on routes of DNA vaccine immunization
下载PDF
导出
摘要 核酸疫苗的接种有多种途径，包括肌内、皮内、皮下注射途径、基因枪免疫、黏膜免疫途径等。不同免疫途径的免疫机制不同，所诱导的免疫保护力的强弱和维持的时间也不尽相同。该文对DNA疫苗免疫各种途径的研究现状作一综述。 There are many routes of DNA vaccine immunization, including intramuscular injection,intradermal injection, subcutaneous injection, gene gun immunization, mucosa immunization, and so on. Different inoculation routes could resuh in different immunologic potency and persistent time. This review summarized the current situation of study on mutes of DNA vaccines immunization.
作者 胡媛 石佑恩
机构地区 华中科技大学同济医学院病原生物系
出处 《国际医学寄生虫病杂志》 CAS 2007年第2期98-102,共5页 International JOurnal of Medical Parasitic Diseases
关键词 DNA疫苗 免疫途径 免疫机制 DNA vaccine Route of immunization Immunologic mechanism
分类号 R392-33 [医药卫生—免疫学]
  • 相关文献

参考文献40

  • 1Da'dara AA, Skelly PJ, Fatakdawala M, et al. Comparative efficacy of the Schistosoma mansoni nucleic acid vaccine, Sm23, following microseeding or gene gun delivery. Parasite Immunol,2002, 24(4) : 179-187.
  • 2McCluskie MJ, Brazolot Millan CL, Gramzinski RA, et al. Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates. Mol Med, 1999, 5 (5) :287-300.
  • 3Ert HC, Xiang Z. Novel vaccine approaches. J Immunal, 1996,156 (10) : 3579-3582.
  • 4McMahon JM, Wells DJ. Electroporation for gene transfer to skeletal muscles : current status. BioDrugs, 2004, 18 (3) : 155-165.
  • 5Wolff JA, Dowry ME, Jiao S, et al. Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle. J Cell Sci, 1992,103 (Pt4): 1249-1259.
  • 6Tuteja R. DNA vaccines: a ray of hope. Crit Rev Biochem Mol Biol, 1999, 34(1) : 1-24.
  • 7Levy MY, Barron LG, Meyer KB, et al. Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther, 1996, 3(3) : 201-211.
  • 8许雪梅,宋国兴,等.DNA疫苗机制研究进展[J].微生物学免疫学进展,2002,30(1):65-70. 被引量：10
  • 9Forg P, von Hoegen P, Dalemans W, et al. Superiority of the ear pinna over muscle tissue as site for DNA vaccination. Gene Ther,1998, 5(6) : 789-797.
  • 10Ayash-Rashkovsky M, Weisman Z, Zlotnikov S, et al. Induction of antigen-specific Thl-biased immune responses by plasmid DNA in Schistosoma-infected mice with a preexistent dominant Th2 immune profile. Biochem Biophys Res Commun, 2001, 282 ( 5 ) :1169-1176.

二级参考文献41

  • 1梁俊峰,薛田,曹玮,蔡国平,郑昌学,周玲,曾毅.基因枪介导的HBsAg基因免疫[J].科学通报,1996,41(9):840-842. 被引量：3
  • 2张芳 周志红 等.不同载体质粒对基因免疫活性影响的研究.畜禽重大疫病生物技术防治研究[M].中国农业科技出版社,1998.134.
  • 3[1]Oxenius A, Bachmann MF, Mathis D, et al. Functional in vivo MHC class Ⅱ loading by endogenously synthesized glycoprotein during viral infection[J] .J. Immunol 1997,158:5717-5726.
  • 4[2]LindsayWhitton. J,Rodriguez. F,Zhang. J,et al. DNA immunization: mechanistic studies[J]. Vaccine 1999,17:1612-1619.
  • 5[3]Robinson HL,Torres Celia A. T. DNA Vaccines[J]. Immunology 1997, Vol 9: 271-283
  • 6[4]Fynan EF, Webster RG, Fuller DH, et al. DNA vaccines: a novel approach to immunization [J]. Int. J. Immunopharmacol 1995,17: 79-83.
  • 7[5]Yokoyama M, Zhang J, Whitton JL, DNA immunization confers protection against lethal lymphocytic choriomeningitis virus inflection[J]. J. Virol 1995,69: 2684-2688.
  • 8[6]Yankauckas MA,Morrow JE, Parker SE, et al. Long term antinucleoprotein cellular and humoral immunity is induced by intramuscular injection of plasmid DNA containing NP gene[J]. DNA Cell Biol 1993,12:771-776.
  • 9[7]Yokoyama M,Hassett DE,Zhang J,et al. DNA immunization can stimulate florid local inflammation and the antiviral immunity induced varies depending on injection site[J]. Vaccine 1997, 15:553-560.
  • 10[8]Davis HL, Millan CL, Watkins SC. Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigenexpressing plasmid DNA[J]. Gene Ther 1997,4:181-188.

共引文献17

同被引文献22

  • 1任淑萍,万敏,丛宪玲,吴秀丽,王莉,卫红飞,王燕媚,于永利,王丽颖.卡介苗作为抗肿瘤重组蛋白疫苗佐剂的研究[J].中国免疫学杂志,2007,23(6):526-530. 被引量：5
  • 2WORLD HEALTH ORGANIZATION.BCG vaccine.WHO position paper[J].Wkly Epidemiol Rec,2004,79(4):27-38.
  • 3DESBIEN A L,REED S J,BAILOR H R,et al.Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist,GLA,via inflammatory caspases,IL-18,and IFN-γ[J].Eur J Immunol,2015,45(2):407-417.
  • 4ORR M T,DUTHIE M S,WINDISH H P,et al.My D88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant[J].Eur J Immunol,2013,43(9):2398-2408.
  • 5CAPRONI E,TRITTO E,CORTESE M,et al.MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action[J].J Immunol,2012,188(7):3088-3098.
  • 6DA'DARA A A,SKELLY P J,FATAKDAWALA M,et al.Comparative efficacy of the Schistosoma mansoni nucleic acid vaccine,Sm23,following microseeding or gene gun delivery[J].Parasite Immunol,2002,24(2):179-187.
  • 7GRIFFITHS P D,STANTON A,MCCARRELL E,et al.Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients:a phase 2 randomised placebo-controlled trial[J].Lancet,2011,377(9773):1256-1263.
  • 8DEY A K,BURKE B,SUN Y,et al.Use of a polyanionic carbomer,Carbopol971P,in combination with MF59,improves antibody responses to HIV-1 envelope glycoprotein[J].Vaccine,2012,30(17):2749-2759.
  • 9WORLD HEALTH ORGANIZATION.Global tuberculosis report2014[R/OL].(2014-10-22)[2015-05-02].http://apps.who.int/iris/handle/10665/75938?locale=en.
  • 10O'HAGAN D T,WACK A,PODDA A.MF59 is a safe and potent vaccine adjuvant for flu vaccines in humans:what did we learn during its development[J].Clin Pharmacol Ther,2007,82(6):740-744.

引证文献1

二级引证文献1

国际医学寄生虫病杂志
2007年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部