胰腺实性-假乳头状瘤2例报告并文献复习

Solid-Pseudopapillary Tumor of Pancreas:Two Cases Report and Literature Review

目的:探讨胰腺实性-假乳头状瘤的临床病理及免疫组化特点,组织起源及生物学行为。方法:对2例SPT进行大体、HE及免疫组化染色观察。结果:肿瘤体积较大,有包膜,囊实性相间。镜检:肿瘤由乳头和囊实性区混合组成,细胞形态一致,核分裂象罕见,瘤细胞围绕纤维血管轴心形成特征性假乳头结构。2例Vim、AAT、AACT及PR阳性;EMA、Actin、S-100、ER阴性;1例Syn、NSE阳性;另1例Syn、NSE阴性。结论:SPT是胰腺少见的肿瘤,其诊断和鉴别诊断主要靠组织病理学,组织起源有争议,可能起源于多能干细胞,属于低度恶性肿瘤。

Objective：To study the clinicopathologie and immunohistochemical characteristics of solid-pseudopapillary tumor of pancreas （SPT）. Methods： 2 cases of SPT were studied by using histologic, HE and immunohistochemistry （S-P method）. Results：The tumors were larger in size, solid alternately with cystic and circumscribed by capsule. Histologically, they were composed of papillary and microcystic solid structures, with uniformed population of cells. The nuclears were oval ,round without atypia,and rate mitotic figures. Pseudopapilla with fibro-vascular core was remarkable. Immunohistochemistry, all cases expressed Vim, AAT, AACT, and PR. Negatived for EMA, Actin, S-100, ER ; 1 case expressed Syn ,NSE. Conclusions ：The origin of SPT is totipotential primordial cells found in the development of the embryonic pancreas. It is a tumor of low-grade malignant.