牛磺酸对青霉素诱导的急性癫痫大鼠行为变化的影响

Effects of Taurine on Behavior of Epileptic Rats Induced by Penicillin

目的观察牛磺酸对青霉素诱导的急性癫痫大鼠行为变化的影响。方法青霉素致痫大鼠模型采用腹腔注射青霉素(320万U/kg)法制作。将成年健康雄性Wistar大鼠45只随机分成正常对照组、癫痫模型组和牛磺酸治疗组(在造模前3天,每只大鼠每天腹腔注射2g/kg牛磺酸),每组15只。癫痫模型组和正常对照组大鼠腹腔注射生理盐水。观察并比较3组大鼠的行为变化表现。结果与癫痫模型组相比,牛磺酸治疗组大鼠的痫性发作潜伏期明显延长,痫性行为表现的次数明显少。结论牛磺酸可延缓癫痫的发作潜伏期,减少癫痫发作次数,减轻癫痫发作程度,具有显著的抗痫作用。

Objective To observe the effects of taurine on epileptic behavior of Wistar rat model of epilepsy induced by penicillin. Methods 45 male Wistar rats were randomly divided into three groups（ n = 15 ） ：（1） normal control group, （2）epileptic model group established by intraperitoneal injection of penicillin （3 200 000 U/kg） and （3）the treated group injected intraperitoneally with taurine at a dose of2g · kg^-1 · d^-1 3 days before modeling. The normal control group and epileptic model group treated with normal saline. The changes in epileptic behavior were observed and compared among three groups. Results Compared with epileptic model group, the treated group showed a prolonged latent period and reduced times of epileptic behavior. Conclusion Taurine could prolong the latent period of epilepsy seizures, diminish the symptom and level of epilepsy attack, and has conspicuous anti -epilepsy effect.