24h平均脉压与冠状动脉病变程度的相关性研究

Relationship between 24 h average pulse pressure and severity of coronary artery stenosis

目的:探讨24h平均脉压(APP)与冠状动脉狭窄程度的关系。方法:对408例入选病例均行冠状动脉造影及冠状动脉狭窄评分,根据冠状动脉造影结果将患者分为冠状动脉狭窄组,非冠状动脉狭窄组,测量24h动态血压,评定其与冠状动脉狭窄程度的关系。结果:冠状动脉狭窄组24h平均脉压显著高于非冠状动脉狭窄组,有极显著性差异(P<0.01),多因素logistic逐步回归分析表明24h平均脉压与冠心病冠状动脉狭窄程度呈正相关(r=0.47,P<0.01)。结论:24h平均脉压可作为预测冠心病冠状动脉狭窄严重程度的指标之一。

Objective： To investigate the relationship between average pulse pressure （APP） of 24 h ambulatory blood pressure monitor （ABPM） and severity of coronary artery stenosis. Methods： Four hundred and eight patients were enrolled. All the patients underwent coronary angiography and their 24 h ABPM was performed. Subsequently, the relationship between APP and the severity of coronary artery stenosis was detected. Results.. APP levels were significantly higher in patients with coronary artery disease （CAD） than these in the normal subjects （P〈0. 01）. Multiple regression analysis indicated that APP positively correlated with severity of coronary artery stenosis （r = 0. 47, P〈0.01）. Conclusion.. APP is an independent risk factor and may be one of the predictors of severity of CAD.