急性心肌梗塞患者血清肝细胞生长因子变化的意义

Clinical significance of serum hepatocyte growth factor in patients with acute myocardial infarction

目的:探讨急性心肌梗塞(AMI)患者血清肝细胞生长因子(HGF)水平变化的临床意义。方法:入选58例AMI患者(发病<3h组n=22,3-12h组n=36)于入院即刻采静脉血,测心肌酶谱、高敏感性C-反应蛋白(hs-CRP),同时测定20例性别年龄与之相匹配的健康体检者(对照组)的上述指标。结果:入院时AMI组的血清HGF浓度(1635.8±327.0)pg/ml,较正常对照组的(721.8±67.9)pg/ml明显增高(P<0.001),AMI发病3h内血清HGF水平就比正常对照组显著升高(917.6±73.6)pg/mlvs.(721.8±67.9)pg/ml(P<0.001)。AMI患者血清HGF浓度与hs-CRP呈显著正相关(r=0.45,P<0.001)。结论:AMI患者血清HGF浓度升高,可能与AMI的炎症反应有关;有望成为诊断早期AMI的一个新指标。

Objective： To investigate the clinical significance of changes of level of serum hepatocyte growth factor （HGF） in patients with acute myocardial infarction （AMI） . Methods： HGF was measured in 58 AMI patients, in whom the onset time of 22 patients was less than 3h, 36 patients was 3h to 12h on admission. Enzyme-linked immunosorhent assay （ELISA） was used to detect the HGF level. The 20 normal volunteers were regards as control. Resuits.. Serum HGF levels on admission were significantly increased in patients with AMI[ （1635.8±327.0） pg/ml, P 〈0. 001], compared with normal subjects [（721.8±67.9） pg/ml]. Even in the early stage of AMI （within 3h of onset of chest pain） serum HGF was already elevated [（917.6±73.6） pg/ml, P〈0. 001]. A statistically significant correlation was found between CRP level and serum HGF levels on admission （r=0. 45, P〈0. 001）. Conclusion.. HGF production may he related to the inflammatory response in AMI. HGF levels provide a serological mark for the diagnosis of early AMI.