基质金属蛋白酶-9和妊娠相关血浆蛋白酶A及hs-CRP与急性冠脉综合征的相关性

Correlation among matrix metalloproteinase-9,pregnancy associated plasma protein-A,high sensitive C-reactive protein and acute coronary syndrome

目的:探讨外周静脉血清基质金属蛋白酶-9(MMP-9)、妊娠相关血浆蛋白酶A(PAPP-A)、超敏C反应蛋白(hs-CRP)水平对冠状动脉粥样硬化斑块稳定性的作用。方法:选取43例急性冠脉综合征(ACS)患者为实验组,其中急性心肌梗塞(AMI)23例,不稳定型心绞痛(UAP)20例,稳定型心绞痛(SAP)25例,健康对照组13例,分别测定他们的血清MMP-9、PAPP-A、hs-CRP水平,比较各组的差异及其在ACS组中的相互关系。结果:UAP组和AMI组的MMP-9、PAPP-A和hs-CRP水平非常显著高于对照组(P<0.01),亦显著高于SAP组(P<0.05～<0.01),hs-CRP水平与MMP-9、PAPP-A水平显著相关(r=0.217,0.244,P均<0.05)。结论:MMP-9、PAPP-A、hs-CRP与斑块不稳定性密切相关,其测定有助于ACS的早期防治。

Objective： To investigate the effect of matrix metalloproteinase--9 （MMP--9）, pregnancy associated plas- ma protein--A （PAPP--A）, and high sensitive C--reactive protein （hs--CRP） on the stability of coronary atherosclerotic plaque. Methods： A total of 43 patients with acute coronary syndrome （ACS） were enrolled as experiment group, in which 23 patients with acute myocardial infarction （AMI） and 20 patients with unstable angina （UAP） as well as 25 patients with stable angina （SAP） were studied and 13 health volunteers served as control, The levels of MMP-9 PAPP-A and hs-CRP were detected and compared. Results： The levels of MMP-9, PAPP-a and hs-CRP in experiment group were significantly more than those of control group （P〈0. 01）, SAP group （P〈0. 05- 0.01）. Conclusion： The levels of MMP-9 , PAPP-A and hs-CRP are strongly associated with plaque unstability. They may be applied in the early prevention and management of ACS.