充血性心力衰竭患者C反应蛋白和肌钙蛋白Ⅰ检测的意义

Abnormal changes of C-reactive protein and troponin Ⅰ in congestive heart failure

目的:探讨充血性心力衰竭(Congestive heart failure,CHF)时血清C反应蛋白(CRP)和肌钙蛋白Ⅰ(troponinⅠ,cTnI)异常的变化及其意义。方法:收集CHF患者60例。其中心功能Ⅱ级、Ⅲ级、Ⅳ级各20例。同时选取30例健康人作为对照组。以化学免疫荧光法定量测定血清CRP及cTnI水平。结果:CHF患者血CRP和cTnI水平明显高于对照组(P<0.01),心衰越重,其水平增高越明显;不同程度CHF患者,其组间差异性显著,呈正相关(P<0.01,r=0.735)。CHF纠正后,血CRP和cTnI水平明显下降(P<0.01)。结论:CHF患者血CRP和cTnI变化与CHF严重程度密切相关;而且CRP和cTnI水平呈正相关。

Objective： To investigate the change of C reactive protein and troponin I in congestive heart failure. Methods： The 60 CHF patients were divided three groups according to the degree of heart failure. Serum levels of CRP and cTnl were measured by chemical fluorescence immunosorbant. Results： In CHF patients, the level of serum CRP and cTnl were higher than those of control group （P〈0. 01） . In severe patients, the change of CRP and cTnl was higher than the mild patients. There was a positive correlation between level of CRP and cTnl （r=0. 735, P〈0. 01） in CHF patients. After CHF improvement, the serum CRP and serum cTnl decreased （P〈0. 01）. Conclusion： The level of serum CRP is positive correlated with cTnl level in congestive heart failure.