肌钙蛋白Ⅰ在急性冠脉综合征早期诊断中的价值

Diagnosis value of troponin Ⅰ in the early stage of acute coronary syndrome

目的:通过测定血清心肌酶谱及肌钙蛋白Ⅰ(cTnI)以探讨其对急性冠脉综合征(ACS)早期诊断的价值。方法:采用生化分析仪及诊断试剂盒,检测了78例ACS患者发病后2～24h各时间段各项指标的动态变化。结果:ACS后4h内患者血清cTnI及肌酸激酶同工酶(CK-MB)水平显著升高,较AST、LDH水平有显著差异(P<0.05),6h内已接近高峰值,6h内AST、LDH水平也开始升高,至8h已接近峰值。结论:联合检测血清cTnI及心肌酶谱对ACS的早期(<4h)诊断有很高的价值。

Objective.. To study the diagnosis value of serum myocardial enzyme and troponin Ⅰ （cTnⅠ） in the early stage of aeute coronary syndrome. Methods： From Mar. 2001 to Dec. 2004, 78 eases underwent test of serum myocardial enzyme and troponin Ⅰ in the different stage of acute coronary syndrome （ACS）. Results.. Levels of CK-MB and cTnI significantly increased within 4 h （early stage） of ACS attack compared with levels of AST and LDH （P〈 0. 05）, attained to near peak value within 6 h of ACS attack. the AST and LDH levels significantly increased within 6 h, and attained to near peak value after 8 h of ACS attack. Conclusion.. The combining test of myocardial enzyme and troponin Ⅰ in early stage （〈4 h） of acute coronary syndrome is very important.