舒血宁治疗糖尿病肾病的观察与护理

Investigation and nurse of diabetic nephropathy treated with shuxuening

目的:探讨舒血宁治疗糖尿病肾病的效果及护理方法。方法:测定40例糖尿病肾病患者治疗前及应用舒血宁治疗后血浆内皮素(ET)、血管紧张素Ⅱ(AngⅡ)、一氧化氮(NO)、肾上腺髓质素(ADM)水平及尿白蛋白排泄率(UAER)变化。结果:糖尿病肾病组ET、AngⅡ、ADM水平明显高于对照组,ET、ADM明显高于糖尿病无肾病组(P均<0.01)。应用舒血宁治疗后糖尿病肾病患者血浆ET、AngⅡ、ADM水平明显降低,NO水平明显升高,UAER明显降低(P均<0.01)。结论:早期采用全面的护理干预,应用舒血宁可显著改善糖尿病肾病患者的病情。

Objective.. To study the effect of treated with shuxuening on diabetic nephropathy and its nursing method. Methods： The serum concentrations of endothelin （ET）, angiotensionⅡ （Ang Ⅱ ） , nitric oxid （NO）, adrenomedullin （ADM） and urinary albumin excretion rate （UAER） were measured in 40 diabetic patients with nephropathy before and after treatment with shuxuening. Results： The plasmic levels of ET, AngⅡ, ADM and UAER increased; NO decreased in diabetic patients with nephropathy than those of control group （P〈0. 01 all） and diabetic patients without nephropathy （except Ang Ⅱ ） （P〈0. 01 all）. The plasmic concentrations of ET. Ang Ⅱ . ADM, NO and UAER significantly （P〈0. 01 all） improved in diabetic patients with nephropathy after treat, ment with shuxuening （P〈0.01 all）. Conclusion： Nurse early and treated with shuxuening may improve the patients condition of diabetic nephropathy.