结核分支杆菌在密集人群中感染的调查与分析

Survey and analysis of Mycobacterium tuberculosis infection in dense population

目的探讨结核分支杆菌在密集人群中的感染状况。方法选择某高校4 896名一、二年级学生和568名农民工,进行结核菌纯蛋白衍生物(PPD)试验。强阳性反应者予胸部X线检查,有异常者再检查痰涂片抗酸染色、痰结核菌培养及血清抗结核抗体。结果PPD阴性反应2 860人,阳性反应2 318人,强阳性反应232人。X线检查肺部有异常者11人,1人淋巴结肿大,痰涂片和培养均为阴性,血清抗结核抗体均为阳性。确诊肺结核病11人,淋巴结结核病1人。来自城镇地区学生的PPD反应阳性率为55.03%,明显高于来自农村地区的学生42.78%(u=7.66,P<0.01),大学生结核病的发现率为0.18%;农民工的PPD反应阳性率55.81%,结核病的发现率0.53%。结论结核分支杆菌的感染在高校学生和农民工中流行形势十分严峻,应该加强结核病疫情管理。

Objective To explore the infected situation of Mycobacterium tubereulosis in dense population. Methods Totall 4896 students who came farm a university in the first or second grade and 568 migrate workers who from a manufactory were received tuberculin（PPD） skin test. All of the students and workers who have strongly positive reaction to PPD were given chest X-ray examination. The persons who have abnormal shadow in their lungs wore further examined with sputum smear acid-fast staining,sputum Mycobacterium culture,and antitubercle antibody in serum. Results Negative reaction：2.860 persons;posltlve reaction：2.318 persons;strongly positive reaction：2.32 persons. Of 232 persons,eleven have abnormal shadows in their lungs ;one has lymphadenectasis ;sputum smear acld-fast strain and cultivate were negative ;serum and antitubercle antibody was positive. Eleven persons were diagnosed as pulmonary tuberculosis and one was diagnosed as lymphoid tuberculosis. The positive rate of PPD reaction of the students who came from urban areas （55. 03% ） was higher than that of rural areas （42. 78% ）, （ u = 7. 66, P 〈 0. 01 ）. The discovery rate of tuberculosis in students was 0. 18%. While, the positive rate of PPD was 55. 81%, and the discovery rate of tuberculosis was 0. 53% in migrate workers. Condusions The infection of Myeobacterium tuberculosis is still extremly stem in universty campus and migrat workers. We should reinforce the adminstration of tuberculosis.