摘要
目的:观察单向白蛋白透析滤过技术对模拟肝衰竭患者血浆的净化作用。方法:利用单向白蛋白透析滤过或持续性静-静脉血液透析滤过处理含有一定浓度代谢产物的血浆,检测治疗前后血浆中胆红素,胆汁酸,氨,尿素和肌酐浓度,并利用SPSS 10.0软件进行统计学分析。结果:单向白蛋白透析滤过可显著降低血浆胆红素水平,而持续性静-静脉血液透析滤过对胆红素水平无显著影响。胆汁酸的降低幅度在单向白蛋白透析滤过组显著高于持续性静-静脉血液透析滤过组。两种方法对水溶性代谢产物氨、尿素和肌酐的清除作用相似。结论:单向白蛋白透析滤过清除血浆中白蛋白结合物质的作用强于持续性静-静脉血液透析滤过,对水溶性物质的清除,二者作用相似。
Aim：To evaluate the detoxication capacities of single-pass albumin diafiltration （SPADF） in vitro. Methods： In each experiment quantitative toxin-loaded human plasma was processed by SPADF or CVVHDF. levels of bilirubin, bile acids, ammonia, urea and creatinine were determined. Concentrations before and after application of detoxication procedures were expressed as differences and were compared using the SPSS 10. 0 software. Results： SPADF induced a significant reduction in bilirubin levels than CVVHDF. SPADF induced a signicanfly reduction of bile acid levels than CVVHDF. No significant differences were found between SPADF and CVVHDF with respect to other water-soluble substances. Conclusion： The detoxication capacity of SPADF for albumin-bounding substances is stronger than that of CVVHDF.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2007年第2期160-163,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
广东省科学技术厅-广东省粤港地区重大领域项目招投标(2005A11304005)
关键词
白蛋白透析滤过
肝衰竭
肝
人工
albumin diafiltration
liver failure
liver
artificial
