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脂联素与非酒精性脂肪性肝病

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摘要 非酒精性脂肪性肝病(non—alcoholic fatty liver disease,NAFLD)是临床常见肝病之一,包括从单纯的肝脂肪变性到非酒精性脂肪性肝炎,以及可最终发展为肝硬化的一组肝脏慢性临床病理综合征,其病因及发病机理至今尚未完全阐明。脂联素为新发现的一种脂肪细胞因子,具有增加胰岛素敏感性、抗炎、增加葡萄糖摄取、促进脂肪酸氧化等作用,已有研究认为与NAFLD关系密切,本文就此作一综述。
出处 《现代医药卫生》 2007年第9期1327-1328,共2页 Journal of Modern Medicine & Health
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  • 1Statnick MA,Beavers LS,Conner LJ,et al.Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes[J].Int J Exp Diabetes Res,2000,1:81.
  • 2Xu A,Wang Y,Keshaw H,et al.The role of the novel adipocytederived hormone adiponectin in human disease[J].Eur J Endocrinol,2003,148:293.
  • 3Yamauchi T,Kamon J,Ito Y,et al.Cloning of adiponectin receptors that mediate antidiabetic metabolic effects[J].Nature,2003,423:762.
  • 4Sligte K,Bourass I,Sels JP,et al.Non-alcoholic steatohepatitis:review of a growing medical problem[J].Eur J Intern Med,2004,15:10.
  • 5Kaser S,Moschen A,Cayon A,et al.Adiponectin and its receptors in non-alcoholic steatohepatitis[J].Gut,2005,54:117.
  • 6Yamauchi T,Kamon J,Minokoshi Y,et al.Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase[J].Nat Med,2002,8(11):1288.
  • 7Maeda N,Shimomura I,Kishida K,et al.Diet-induced insulin resistance in mice lacking adiponectin/ACRP30[J].Nat Med,2002,8(7):731.
  • 8Mantzoros CS,Li T,Manson JE,et al.Circulating adiponectin levels are assoeiaetd with better glycemic control,more favorable lipid profile,and reduced inflammation in women with type 2 diabetes[J].J Clin Endocrinol Metab,2005,90:4542.
  • 9Kawanami D,Maemura K,Takeda N,et al.Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells:a new insight into adipocytokine-endothelial cell interactians[J].Biochem Biophys Res Commun,2004,314:415.
  • 10Manigrasso MR,Ferroni P,Santilli F,et al.Association between circulating adiponcetin and interleukin-10 levels in android obesity:effects of weight loss[J].J Clin Endocrinol Metab,2005,90:5876.

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