尿毒症患者胃镜下改变及临床分析

Analysis of changes in gastroscopy and clinical features of uremic patients

目的观察尿毒症患者上消化道黏膜病变的情况并分析其与临床症状和透析的关系。方法对134例尿毒症患者进行胃镜检查,分析各型黏膜病变患者的临床症状及透析情况,作相关分析。结果所有患者均有不同程度的胃黏膜损伤,部分患者合并十二指肠或食管黏膜损伤。其中以慢性浅表性胃炎和慢性糜烂性胃炎为主,约占50%,胃和十二指肠溃疡的发生率不足20%。经统计,透析和未透析患者胃镜下各种病变的发生率差异无显著。有消化道症状和无症状患者胃镜下各种病变的发生率差异有显著。结论尿毒症患者上消化道黏膜病变发生率高,病变类型与临床症状具有一定相关性,透析治疗对上消化道黏膜病变并无显著治疗作用。

[Objective] To observe upper digestive tract mucosa lesions of uremic patients and to analysis the association among mucosa lesions and clinical symptom and dialysis. [Methods] 134 uremic patients accepted gastroscopy, we analysis the clinical symptoms and dialysis stats of all types of mucosa lesions. [Results] All patients had gastric mucosa lesion of different degrees, part of them still had duodenal or esophageal mucosa lesion. The major types of lesions were chronic superficial gastritis and chronic erosive gastritis, accounting for 50 percent. The incidence of gastric ulcer and duodenal ulcer was no more than 20 percents. The incidences of all types of mucosa lesions had no significant difference between patients accepted dialysis and conservative therapyl The incidences of all lesion types had significant difference between patients had digestive tract symptoms and had no symptoms. [ Conclusions] The incidences of upper digestive tract mucosa lesions of uremic patients were high,the lesion types had certain correlation with clinical symptoms, and dialysis treatment has no significant effect to mucosa lesion.