帕金森病人运动并发症发生机制研究

Study of Motor Complications in Parkinsonian Patients

目的探讨帕金森病人运动并发症的发生机制及帕金森病人的最佳治疗方案。方法66例帕金森病人,主要观察年龄、性别、病程、多巴胺剂量、多巴胺疗程与运动并发症的关系。结果帕金森病人年龄、病程、多巴胺剂量、多巴胺疗程与运动波动及异动症有关。结论帕金森病人病程、多巴胺剂量、多巴胺疗程是运动并发症的独立危险因素,年龄是保护性因素。

Objective： To explore the mechanism of motor complications and to explore the best way treatment in parkinsonian patients. Methods： 66 cases with parkinsonian patients. The mainly analysed were age,at onset of PD, sex, disease duration, dosage of levodopa（ LD）, duration of LD treatment and relation to motor complications. Results： Disease duration,dosage of LD, duration of LD treatment related to the development of motor factors fluctuations and dyskinesias. Conclusion： Disease duration,dosage of LD,duration of LD treatment were independent factors for the development of motor complications.