Tei指数评价卡维地洛治疗慢性心衰疗效

Evaluate The Effect of Carvedilol in the Treatment of Chronic Heart Failure by the Tei index

目的探讨卡维地洛对慢性心力衰竭的疗效,并用Tei指数进行评价。方法67例慢性心力衰竭患者随机分为治疗组(n=32)和对照组(n=35),两组均应用ACEI、利尿药和洋地黄制剂基础抗心衰治疗:治疗组加用卡维地洛(15±3.6 mg/天);对照组加用安慰剂。分别于治疗前及治疗后3月、6月后测定LVEF、SI、CI、E/A、LVDD、Tei指数。结果①卡维地洛治疗3个月后,Tei、SV、CI、E/A显著改善P<0.05,对照组以上指标无显著差异P>0.05;治疗6个月后治疗组和对照组LVEF、LVDD、SV、CI、E/A、Tei均显著改善P<0.01;②6个月后治疗组LVEF、SI、CI、E/A、LVDD、Tei指数均较对照组有显著差异P<0.05。结论卡维地洛治疗可显著改善心衰病人心功能,Tei指数与常规超声测量的心功能指标均能很好反映心功能变化,且Tei指数较LVEF、LVDD更敏感。关键词:卡维地洛;慢性心衰;

Objective. To probe the effect of Carvedtiol in the treatment of chronic beart failure and evaluate its effect with the Tei index, Methods： Sixty- seven patients with chronic heart failure were randomly divided into treatment group（ n = 32） and control group （ n = 35 ）. All the patients were treated with ACEI. diuretic and digoxin . the treatment group was treated with carvediloi （ 15 ± 3.6 mg/d）while the control group was treated with piacebo.the LVEF;SI,CI,E/A,LVDD.Tei index were measured before and after 3,6 months . Results： 1. After 3 months of Carvediloi treatment only the Tei index,SV,CI,E/A were significantly improved in the treatment group, but in the control group there is no significantly changement. 2. after 6 months. all the LVEF,SI,CI,E/A,LVDD,Tei index were significantly improved In the treatment grip （P 〈0.05 ）. Conciusions. Carvediiol can improve the cardiac function significgntly. Tei index was more sensitive than the other index.