稀土离子(La^(3+),Gd^(3+),Yb^(3+),Ce^(3+))对线粒体的氧化损伤

Effects of Lanthanide Ions(La^(3+),Gd^(3+),Yb^(3+) and Ce^(3+)) on Mitochondrial Oxidation Damage

主要考察了稀土离子对线粒体氧化损伤(膜脂质过氧化、膜蛋白氧化、线粒体DNA氧化)的作用。结果表明,稀土离子(La3+,Gd3+,Yb3+,Ce3+)浓度大于2×10-5mol.L-1时,对线粒体膜脂质过氧化、膜蛋白氧化均有明显的促进作用;在对Fe2+诱导的线粒体氧化过程中,La3+,Gd3+和Yb3+能明显地增强Fe2+的氧化作用,而Ce3+对Fe2+的作用表现出明显的拮抗作用,此外Ce3+对Fe2+诱导的线粒体DNA氧化损伤表现出明显的拮抗作用,显示了Ce3+的特殊性。

The influences of lanthanide （Ln） on the oxidative injury of mitochondria were investigated. Ln ions （La^3 ＋ , Gd^3 ＋ , Yb^3 ＋ , Ce^3 ＋ ） at the concentrations of 2 × 10-3 mol· L^-1 could promote the mitochondrial membrane lipid peroxidation and membrane protein oxidation. In the process of Fe^2 ＋ -induced oxidation of mitochobdfia, La^3＋, Gd^3＋ and Yb^3＋ could obviously enhance the effects of Fe^2＋. However, Ce^3＋ showed the opposite effects. Similar effects of Ln were observed on the oxidation of mitochondrial DNA.