术中应用肝素抑制后发性白内障的临床研究

Effect of Heparin by Hydrodissection on Prevention of Posterior Capsule Opacification in Patient Eyes

目的探讨水分离时应用肝素对人后发性白内障形成的影响。方法将60只眼随机分为对照组和用药组,在人晶状体囊外摘除术中,用25U/ml肝素在晶状体囊袋内进行水分离,使其直接短暂作用于晶状体上皮细胞。术后观察半年,行后囊混浊评分,比较各组晶状体后囊混浊情况。结果术后半年对照组有15只眼发生后囊混浊,后囊混浊评分5只眼II级,10只眼I级,用药组有4只眼发生后囊混浊,后囊混浊评分3只眼I级,1只眼II级,低于对照组,两组间比较差异有显著性(P<0.05)。结论水分离时使用肝素可减少早期前房反应,抑制后发性白内障的形成。

Objective To investigate the inhibitory effect of heparin on posterior capsule opacification （PCO）. Methods 60 patients were randomly divided into control and experiment groups. Heparin （25U/ml） were injected into capsular bags by hydrodissection during extracapsular cataract extraction （ECCE） in patient eyes. The changes observed by slit-lamp microscope. Results of the cornea, anterior chamber and posterior capsule were Six months posteoperatively,15 eyes in the control group developed PCO（ the score of 5 eyes was graded as Ⅱ and 10 eyes was graded as Ⅰ） ,4 eyes in the heparin group developed PCO（the score of 1 eye was graded as Ⅱ and 3 eyes was graded as Ⅰ）. The PCO incidence of the heparin group was lower than that of the control group. There was significant diference between the two groups（ P 〈0. 05）. Condusion The results suggest that the application of heparin by hydrodissection effectively reduce PCO and anterior chamber reaction in patient eyes.