组织型纤溶酶原激活剂及其抑制剂与肺血栓栓塞症

Relationship between tissue plasminogen activator and plasminogen activator inhibitor and pulmonary thromboembolism

肺血栓栓塞症（PTE）的发病与机体的纤溶和凝血系统功能密切相关。组织型纤溶酶原激活物（t-PA）及其抑制物（PAI-1）因调节机体的纤溶系统而在静脉血栓形成及栓塞性疾病的发病机制中发挥重要作用，因此，本文对t—PA和PAI-1与PTE的关系作如下综述。

The incidence of pulmonary thromboembolism （PTE） is associated with the balance between fibrinolysis and coagulation. As a result of the regulation in the fibrinolytic system, tssue plasminogen activator （t-PA） and plasminogen activator inhibitor type 1 （PAI-1） play an important role in the pathogenesis of venous thrombosis and embolism. Thus, this review is about the relationship between t- PA,PAI-1 and PTE.