弥漫性泛细支气管炎气道黏液高分泌的研究进展

Advance on mucus hypersecretion of diffuse panbronchiolitis

弥漫性泛细支气管炎是一种小气道慢性炎症性疾病，气道黏液高分泌即痰液增多是该病主要临床表现之一。其黏液高分泌的机制至今尚不清楚，相关研究表明与绿脓杆菌、中性粒细胞、炎症介质及黏蛋白基因的多态性有关。另外，大环内酯类抗生素对弥漫性泛细支气管炎的气道高分泌有显著治疗作用。

Diffuse panbronchiolitis （DPB） is a chronic progressive disease of the lower respiratory tract,and is characterized by mucus hypersecretion. But the detailed mechanisms of mucus production have not been well defined. According to in vivo and in vitro studies, Pseudomonas aeruginosa, neutrophil infiltration,inflammatory stimuli and MUCsB gene polymorphisms play important roles in the process of hypersecretion. In addition,long-term treatment with macrolide antibiotics has been proved efficient in mucus overproduction of diffuse panbronchiolitis.