非淋菌性尿道炎支原体的检测和药敏试验分析

Analysis on Detection and Susceptibility of Mycoplasma in Non-gonococcal Urethritis

目的探讨非淋菌性尿道炎(NGU)的感染情况以及对药物的敏感性。方法对450例病人做支原体培养及12种抗生素药敏试验。采用支原体培养、鉴定、药敏一体化试剂盒进行检测。结果支原体培养阳性153例(34.0%),解脲支原体UU阳性115例(25.6%),人型支原体MH阳性9例(2.0%),UU+MH阳性29例(6.4%)。UU对12种药物敏感性最高为交沙霉素(99.1%),其次为强力霉素、美满霉素及四环素,分别为96.5%、95.7%及94.8%。耐药性最高为环丙沙星(64.3%),其次是司帕沙星、氧氟沙星及可乐必妥,分别是40.0%、40.0%和39.3%。结论加强支原体的药敏检测,根据药敏结果合理用药,对防止支原体耐药株产生具有重要意义。

Objective To determine the mycoplasma infection and the drug susceptibility in non - gonococcal urethritis （NGU） patients. Methods The mycoplasma culture was carried out from samples of 450 patients and the susceptibility of mycoplasma to twelve kinds of antimicrobial agents was tested. The mycoplasma positive rate and the drug susceptibility were calculated with a complex mycoplasma kit. Results Of the 450 patients, 153 were infected with mycoplasma, and the total positive rate was 34.0 %. The positive rates of UU, MH and the mixed infection were 25.6 % （115）, 2.0 % （9）, and 6.4% （29） respectively. The highest susceptibility rate of UU to twelve antimicrobial agents was Josamycin（99.1% ）, fol- lowed by Doxycycline（96.5 % ）, Minocycline（95.7 % ）, and Tetracyclinum （94.8 % ）. The highest drug resistantce rate of UU was Oiprofloxacin（64.3% ）, followed by Spaxacin （40.0%）, Oravit（40.0 % ）, and Ofloxacin（39.3% ）. Conclusion It is important to enhance the detection of drug resistance of mycoplasma for guiding appropriate use of drugs and preventing from producing antibiotic- resistant mycoplasma.