摘要
目的探讨乌司他丁(UTI)对急性肺损伤(ALI)小鼠肺组织中白细胞介素-10(IL-10)表达的影响。方法将昆明种小鼠50只随机分为脂多糖(LPS)组和UTI组,腹腔注射LPS建立小鼠急性肺损伤模型,用放射免疫法测定各组各时相点肺组织匀浆上清液中IL-10的含量,同时观察肺组织形态学改变。结果两组小鼠肺组织中IL-10含量均呈上升趋势,UTI组升高幅度明显高于LPS组(P<0.05)。结论UTI可能通过上调抗炎因子IL-10的表达,对ALI小鼠产生保护作用。
Objective To investigate the effect of ulinastatin on the expression of IL- 10 in lung tissues of acute lung injury mice. Methods Fifty mice were randomly divided into 2 groups： LPS group and UTI group. The ALI model was set up by intraperineal injection of lipopolysaccharide （LPS）. The changes of IL-10 levels in the pulmonary tissues were detected by ELISA at defferent times. Besides, observing the lung histological manifestations. Results The levels of IL- 10 in two groups mice all took on a ascending trend,being higher in UTI group（ P 〈 0.05）. Conclusion UTI can lessen the acute lung injury,which may be the mechanism through up- regulating the anti- inflammatory factor.
出处
《中国药业》
CAS
2007年第9期10-11,共2页
China Pharmaceuticals
