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胃肠道间质瘤的诊断治疗分析 被引量:1

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摘要 目的探讨胃肠道间质瘤(GIST)的诊断及治疗特点。方法回顾分析2002—2005年重庆市肿瘤医院腹外科收治的8例GIST患者的临床资料。结果患者男女比为1.7∶1,平均年龄56.5岁,肿瘤部位以胃肠为主,肿瘤平均大小6.8cm,全部行局部切除术或根治性切除术,免疫组化分析显示CD34阳性率为75%,CD117阳性率为90%,病理报告均证实为恶性间质瘤,术后未行放化疗,未口服格列卫,2年死亡率为75%。结论GIST的诊断依靠免疫组化分析,治疗以手术切除为主,扩大切除及淋巴结清扫意义不大;GIST对放化疗不敏感,分子靶向药物格列卫能减少复发、提高生存率,应用前景广阔。
作者 姚烨
出处 《中国药业》 CAS 2007年第9期46-47,共2页 China Pharmaceuticals
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  • 1赵海潞,纪小龙.消化道间叶性肿瘤的新认识[J].新消化病学杂志,1996,4(2):100-101. 被引量:19
  • 2Lewin K J, Riddell R H, Weinstein W M, et al. Gastrointestinal pathology and its clinical implications[J]. Gastroenterology, 1992, 103:284-341.
  • 3Sircar K, Hewlett B R, Huizinga J D, et al. Interstitial cells of Cajal as precursors of gastrointestinal strcmal tumors [J]. Am J Surg Pathol,1999, 23(4):377-382.
  • 4Hirota S, Isozaki K, Moriyama Y, et al. Gain of function mutations of c-kit in human gastrointestinal stromal tumors[J]. Science, 1998, 279:577-580.
  • 5Graadtvanroggen J F, Vanvelehuysen M L F, Hogendoorn P C W, et al.The histopathological differential diagnosis of gastrointestinal stromal tumors[J]. J Clin Pathol, 2001, 54:96-102.
  • 6Miettinen M, Lasota J. Gastrointestinal stromal tumors definition, clinic al, histological, immunohistochemical, and molecular genetic features and defferential diagnosis[J]. Virchows Arch, 2001, 438(1):1-12.
  • 7Charles J. The pezcoller lecture: Cancer cell cycles revisited[J]. Cancer Res, 2000, 60:3689-3695.
  • 8Tekinalp G, Gulsumozlem E, Nazif H A, et al. p27 labeling index and proliferation in gastrointestinal stroma tumors:correations with clinicopathologic factors and recurrence[J]. Jap J of Clin Oncol, 2003, 33:346-352.
  • 9Tekinalp G, Nazif H A, Nuran K, et al. p27 labeling index and proliferation in gastrointestinal stromal tumors: correlations with clinicopathologic factors and recurrence[J]. Jap J of Clin Oncol, 2003, 33:346-352.
  • 10Gelen M T, Elpek G, Ogus M, et al. p27 expression and proliferation in gastrointestinal stromal tumors[J]. Turk Gastroenterol, 2003, 14(2):132-137.

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