法莫替丁与氯醌酸电荷转移反应中超分子作用及其应用

Supermolecule interaction in famotidine-chloranilic acid charge transfer reaction and its application

目的：建立电荷转移分光光度法测定片剂中法莫替丁的含量。方法：法莫替丁作为电子给体，氯醌酸作为电子受体，两者反应生成荷移化合物，在517nm处有最大吸收，对片剂中法莫替丁的含量进行了测定。同时对非水体系中超分子作用机制进行研究。结果：法莫替丁与氯醌酸形成荷移化舍物的表观百分吸收系数为25．4±2．5，稳定常数K为（3．1±0．9）×10^6，测定法莫替丁的线性范围为16．8～285．6mg·L^-1，精密度RSD不大于3．0％，检测限2mg·L^-1，方法回收率为（100．3±2．1）％。在丙酮溶剂中，微量醇对荷移化合物有超分子作用。结论：电荷转移分光光度法测定片剂中法莫替丁的含量快速、准确。

OBJECTIIVE To determinate famotidine in tables by charge transfer spectrophotometry. METHODS The determination was based on the reaction between famotidine and chloranilic acid forming the charge transfer compound. RESULTS The stability constant, the specific absorptivity of charge transfer compound reacted by famotidine and chloranilic acid were （3. 1± 0. 9）× 10^6 ,25. 4 ± 2. 5, respectively. The linear range,ihe precision （RSD）, the determination limit and the recovery of famotidine were 16. 8 - 285.6 mg·L^-1 , 3. 0%, 2 mg· L^-1 and （ 100. 26 ± 2. 1 ） %, respectively. There were supermolecule interaction of micro-amount and small molecule alcohols on the charge transfer compound, in acetone. CONCLUSION The famotidine charge transfer compound is stable. Themethod is precise, accurate, simple and fast, and can be applied for the determination of famotidine in tablets.