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溶胀型骨架片释药机制及其模型研究综述 被引量：7

Release Mechanisms and Modelings of Swellable Matrix Tablets——A Review
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摘要 基于溶胀型骨架的相转变过程、凝胶层特性及其骨架结构特征和前沿移动行为,综述近年来溶胀型骨架片的释药机制及其模型的研究进展。 Based on the phase transition of swellable matrix and the characteristics, special matrix structure and front movement of the gel layer, the researches on release mechanisms and modelings of swellable matrix tablets in recent years were reviewed.
作者 秦婷婷 姚静 周建平
机构地区 中国药科大学药剂学教研室
出处 《药学进展》 CAS 2007年第4期159-165,共7页 Progress in Pharmaceutical Sciences
关键词 溶胀型骨架片 释药机制 模型 溶胀 溶蚀 扩散 前沿移动 Swellable matrix tablet Release mechanism Modeling Swelling Erosion Diffusion Front movement
分类号 R944 [医药卫生—药剂学]
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参考文献25

  • 1Kashyap N, Kumar N, Kumar M. Hydrogels for pharmaceutical and biomedical applications[ J ]. Crit Rev Ther Drug Carr Syst, 2005, 22(2) : 107-149.
  • 2Maggi L, Bruni R, Conte U. High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms[J], Int J Pharm, 2000, 195(1-2):229-238.
  • 3Missaghi S, Fassihi R. Release characterization of dimenhydrinate from an eroding and swelling matrix: selection of appropriate dissolution apparatus [ J ]. Int J Phatm, 2005,293(1-2) : 35-42.
  • 4Colombo P, Bettini R, Santi P, et al. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance [ J ] Pharm Sci Technol Today,2000,3(6) : 198-204.
  • 5N K, Jones A B. Sustained release of acetaminophen from a heterogeneous mixture of two hydrophilie non-ionic eellulcee ether polymers[J], Int J Pharm, 2004, 272(1-2):19-27.
  • 6Komer A, Iarsson A, Piculell L, et al. Tuning the polymer release from hydrophilic matrix tablets by mixing short and long matrix polymers[J]. J Pharm Sci, 2005, 94 (4): 759-769.
  • 7Baumgartner S, Lahajnar G, Sepe A, et al. Quantitative evaluation of polymer concentration profile during swelling of hydrophilic matrix tablets using 1H NMR and MRI methods[J]. Ear J Pharm Biopharm, 2005, 59(2) : 299-306.
  • 8Ghanadzadeh A, Sariri R, Ghanadzadeh H, et al. Effect of poly-HEMA hydrophilic gel environment on the photo-physical behavior of rhodamine dyes [ J ]. Spectrochim Acta Part A,2005, 61(4) :659-663.
  • 9NAzzal S, Nodal M, El-Malah Y. A novel texture-probe for the simultaneous and real-time measurement of swelling and erosion rates of matrix tablets[J], Int J Pharm, 2007, 330(1-2) : 195-198.
  • 10Jamzad S, Tutunji L, Fassihi R. Analysis of macromolecular changes and drug release from hydrophilic matrix systems[J].Int J Pharm, 2005, 292(1-2): 75-85.

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药学进展
2007年 第4期

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