血清总抗氧化能力和丙二醛水平在2型糖尿病颈动脉病变和视网膜病变中的变化

Changes of serum total antioxidant capacity and malondialdehyde concentration in type 2 diabetes with dabetic carotid disease and diabetic retinopathy

目的:探讨糖尿病颈动脉病变和视网膜病变时的氧化应激表现。方法:选择92例2型糖尿病患者,检测血清总抗氧化能力(TAOC)、丙二醛(MDA)浓度及空腹血糖、糖化血清蛋白、糖化血红蛋白、肌酐、尿酸、纤维蛋白原、血脂水平,并进行对照分析。采用彩色多普勒超声判定糖尿病颈动脉病变,采用眼底荧光造影判定糖尿病视网膜病变,按结果将其分为3组:糖尿病无颈动脉病变和无视网膜病变组(DM1组)30例,糖尿病伴颈动脉病变组(DM2组)30例,糖尿病伴颈动脉病变和视网膜病变组(DM3组)32例。结果:(1)TAOC与MDA呈负相关(r=-0.312,P<0.01)。(2)DM2组、DM3组TAOC水平均明显低于DM1组(P<0.05)。(3)DM2组、DM3组MDA水平明显高于DM1组(P<0.05),DM3组MDA水平明显高于DM2组(P<0.05)。结论:氧化应激可能参与2型糖尿病大血管和微血管并发症的发病过程。

Objective： To investigate the role of oxidative stress in diabetic carotid disease and diabetic retinopathy. Methods： Serum level of the total antioxidant capacity （TAOC） and Malondialdehyde （MDA） were measured in 92 patients with type 2 diabetes. Meanwhile,fasting blood glucose, glycosylated serum protein, glycohemoglobin,serum creatinine,blood uric acid, fibrinogen and lipids were detected. The diabetic carotid disease was detected by colour Doppler and diabetic retinopathy was detected by fundus fluroescein angiography. The patients were divided into three groups, the diabetes group without diabetic carotid disease and diabetic retinopathy （DM1） （n = 30）, the diabetes group with diabetic carotid disease （DM2） （n =30）, the diabetes group with diabetic carotid disease and diabetic retinopathy （DM3） （n = 32）. Results： （1） TAOC level was negative correlated with MDA level （r =-0. 312, P 〈0.01）. （2） TAOC concentration was evidently lower in DM2 and DM3 than that in DMI（P〈0.05）. （3）MDA concentration in DM2 and DM3 was significantly higher than that in DM1 （P 〈0. 05）. MDA concentration in DM3 was significantly higher than that in DM2 （P 〈0. 05）. Conclusion. Oxidative stress may participate in the development of type 2 diabetic micro-and macrovascular complications.