摘要
目的通过爱普列特和保列治治疗后患者血清性激素水平变化的研究,为临床提供用药参考。方法2005年在我院就诊的门诊前列腺增生患者88例。分别于治疗开始前和治疗后12周采血测血清性激素(LH、T、f-T、DHT、E2)。结果爱普列特组在治疗12周后E2上升,DHT下降,前后比较有显著性差异(P<0.05)。保列治组在治疗12周后LH上升,T上升,DHT下降,均有显著性差异(P<0.05)。两组治疗后性激素变化比较在LH和T的水平上有统计学意义(P<0.05)。结论爱普列特和保列治是两种不同的Ⅱ型5α-还原酶抑制剂,治疗后对血清性激素的影响也不同。
Objective To find out the changing in serum concentration of sex hormones after the treatment of epristeride and finasteride and to provide reference for medicine treatment of BPH. Methods 88 patients diagnosed as BPH in 2005 were divided in to two groups： epristeride and finasteride and was measured respectively serum concentration of sex hormones （LH, T, DHT, f-T, E2）at the beginning and 12 weeks after treatment. Results There was a difference in E2 and DHT after 12 weeks treatment in epristeride group and a difference in LH,T and DHT after 12 weeks treatment in finasteride group. Conclusion Epristeride and finasteride are different type of 5 α -reductase inhibitors.There are obvious difference between mechanism, active site and the changing in serum concentration of sex hormones after treatment.
出处
《中国男科学杂志》
CAS
CSCD
2007年第3期44-46,50,共4页
Chinese Journal of Andrology
关键词
爱普列特
保列治
前列腺增生
性激素
epristeride
finasteride
benign prostatic hyperplasia
sex hormones
