参附注射液对充血性心衰患者内皮功能的影响

The Effect of Shenfu Injection on Endothelium Function of Patients with congestive Heart Failure

目的观察参附注射液对充血性心衰(CHF)患者血管内皮功能的影响并探讨其作用机制。方法选择30例正常人作为对照组(A组),60例CHF患者随机分为常规治疗组(B组)与参附注射液治疗组(C组);比较B组、C组临床疗效及治疗前后三组血清ET、NO、MDA、SOD含量变化。结果治疗后C组较B组临床疗效明显改善;B组及C组与A组比较,治疗前ET及MDA显著增高,NO及SOD明显降低;C组治疗后SOD活性明显高于B组,MDA含量明显低于B组,均与A组差异无显著;C组治疗后NO水平显著高于B组,ET含量显著低于B组。结论参附注射液具有改善CHF时自由基介导的内皮功能紊乱作用,对衰竭的心肌起到保护作用。

Objective： To observe the effect of Shenfu Injection（SFI, 参附注射液） on endothelium function of patients with congestive heart failure （CHF）, and to probe the mechanism. Methods： Established the contrats group （group A, 30 normotensive subjects）, and 60 patients with CHF were classified into 2 groups randomly, the routinely treatment of WM group（group B）, SFI and routinely treatment of WM -treated group（C） . The effect were observed after the treatment. The concentration of serumal endothelin （ET）, nitric oxide （NO）, total superoxide dismutase （T - SOD） and malonyl- dialdehyde（MDA） were detemined before and after treatment. Results： The curative effect of group C were better than of group B significantly after treatment. Serumal ET and MDA of group B and C increased, NO and T - SOD of the two groups decreased than of group A before the treatment. T - SOD of group C were higher significantly than of group B, MDA were lower significantly after the treatment. They had not differences with group A significantly. NO of group C increased and ET decreased than those of group B after the treatment. Conclusion： SFI can improve the abnormality of endothelium function in which free radicals are involved and protect failing myocardium.