北柴胡及春柴胡挥发油的抗炎镇痛作用的实验研究

Experimental study on anti-inflammatory and analgesic effects of volatile oil of Bupleurum chinense and B.scorzonerifolium

目的:比较北柴胡与春柴胡挥发油抗炎镇痛作用的差异。方法:采用小鼠耳廓肿胀和小鼠腹腔毛细血管通透性实验,比较北柴胡与春柴胡的抗炎作用;以热板法和扭体法比较北柴胡与春柴胡的镇痛作用。结果:北柴胡10 g.kg-1剂量组、春柴胡5 g.kg-1、10 g.kg-1剂量组可对抗二甲苯所致小鼠耳肿胀,可减少醋酸致小鼠毛细血管通透性增加,与模型组比较有显著性差异;北柴胡10 g.kg-1剂量组、春柴胡10 g.kg-1剂量组还可减少小鼠扭体次数,提高小鼠的痛阈值。结论:北柴胡和春柴胡均具有一定的抗炎作用,春柴胡抗炎疗效优于北柴胡。北柴胡和春柴胡对化学性和物理性刺激具有一定的镇痛作用,但两者疗效无显著性差异。

Objective ：To compare the antiinflammatory and analgesic activities between volatile oil of Bupleurum chinense and B. scorzonerifolium. Methods： Anti -inflammatory effects between B. chinense and B. scorzonerifolium, were determined using xylene induced ear edema and abdominal capillary permeability test in mice. Analgesic activities of those two kind of Bupleurum were evaluated using hot-plate test and writhing test. Results： Both 5 g·kg^-1 and 10 g·kg^-1 dosage of B. scorzonerifolium group, as well as 10 g·kg^-1 dosage of B. chinense group produced a significant inhibition of ear edema and the abdominal capillary permeability compared with that of control group. 10 g·kg^-1 dosage of B. scorzonerifolium group and 10 g·kg^-1 dosage of B. chinense group also exhibited a promising reduction in mice writhing and an elevation of the pain threshold compared with that of the control group. Conclusion： Both B. chinense and B. scorzonerifolium possesses certain anti -inflammatory effects, the different was that the effect of the latter one is superior to the other. While there were no significant difference in analgesic effects between them.