溃疡性结肠炎患者血清抗β2糖蛋白Ⅰ抗体水平的检测及其意义

Significance of anti-beta2-glycoprotein I antibodies in ulcerative colitis patients

目的探讨溃疡性结肠炎患者血清中抗β2糖蛋白Ⅰ抗体（aβ2GPⅠ）水平及其意义。方法采用ELISA方法分别对活动期溃疡性结肠炎组、缓解期溃疡性结肠炎组及正常对照组血清中的aβ2GPⅠ水平和阳性率进行检测分析。结果①活动期及缓解期溃疡性结肠炎患者血清中IgM和IgG型aβ2GPⅠ水平明显高于正常对照组；活动期溃疡性结肠炎组与缓解期组相比，IgG型aβ2GPⅠ水平差异亦有统计学意义（P〈0．05）。②在aβ2GPⅠ阳性率的比较中，活动期溃疡性结肠炎组与缓解期溃疡性结肠炎组比较差异有统计学意义；二者与正常对照组相比，差异均有统计学意义。而活动期溃疡性结肠炎组与正常对照组相比差异有统计学意义（P〈0．01）。结论抗β2糖蛋白Ⅰ抗体可能和溃疡性结肠炎的发病机制有关，是其高凝状态的可能原因之一。

Objective To explore the level and significance of anti-beta2-glycoprotein Ⅰ in ulcerative colitis patients. Methods The levels and the positive rates of aβ2 GPⅠ of type IgM and IgG were detected in three groups including active ulcerative colitis,inactive ulcerative colitis and normal control by using ELISA. Results There were both significant increase of the levels of IgM and IgG aβ2 GPⅠ in active groups and inactive ulcerative colitis groups than in normal control group. There was also ficant difference on the levels of aβ2 GPⅠ of IgG between active ulcerative colitis group and inactive ulcerative colitis one （ P 〈 0.05 ）. On the positive rates of aβ2 GPⅠ , there was statistical significance between active ulcerative colitis group and inactive ulcerative colitis one; They had both remarkable difference with the normal control, especially, active ulcerative colitis group （ P 〈 0.01 ）. Conclusion Anti-beta2- glycoprotein Ⅰ antibodies maybe play a role in the pathogenesis of ulcerative colitis and is a possible reason for its hy- percoagulabale state.