儿童呼吸道感染肺炎衣原体的检测及意义

Detection of Chlamydia Pneumonia in Children's Respiratory and Its Significance

目的探讨肺炎衣原体(简称CPn)在儿童急性呼吸道感染中的发病情况及临床特征,为临床诊断及治疗提供参考依据。方法急性呼吸道感染患者142例,健康儿童52例,取静脉血,采用酶联免疫吸附试验(ELISA)检测CPn。结果观察组CpnIgG阳性者30例(占21.1%),对照组4例(占7.7%),两组比较差异有统计学意义(P<0.005)。观察组中有CPn急性感染抗体的有22例(占15.5%),对照组中无CPn急性感染,两组比较差异有统计学意义(P<0.005)。下呼吸道感染患者的CPn急性感染率为17.8%,上呼吸道感染患者为4.2%,两组比较P<0.05。CPn急性感染的临床表现无特征性。结论CPn是儿童急性呼吸道感染的重要致病原。

Objective To evaluate the infected rate and the clinical feature of children with acute respiratory infection caused by Chlamydia pneumonia （ CPn）, and to provide the basis of diagnosis and treatment, Methods A prospective study on CPn infection was conducted in 142 patients with acute respiratory diseases and 52 healthy children. Anti-CPn IgG and IgM were detected by ELISA. Results IgG was positive in 30 patients （ 21. 1% ）, and four patients （ 7.7% ） in healthy children （ P 〈 0.005）. 22 patients （ 15.5% ） had anti-CPn IgM, but the healthy children had not （P 〈 0,005）. The acute infection rate of CPn in lower respiratory tract （ 17.8% ） was statistically higher than in upper respiratory tract （4.2%） （P 〈 0.05 ）. The clinical feature of CPn infection was not specific. Conclusions Data suggest that Chlamydia pneumonia is an important pathogen that causes acute respiratory infection in children.