浙江省湖州地区戊型肝炎血清学研究

Seroepidemiological investigation of hepatitis E in the region of Huzhou

目的了解戊型肝炎在自然人群中的感染情况、流行特征。方法在浙江省湖州市范围内按农村平原水乡、农村山区和城镇三群,随机抽取1666名健康人群为研究对象,用酶联免疫吸附实验(ELISA)方法测定血清戊型肝炎抗体(抗-HEVIgG),同时调查相关危险因素。结果抗-HEVIgG阳性749例,感染率为44.96%,标化率为38.88%。感染率随年龄增长而升高,平原水乡、城镇显著高于山区,且存在家庭聚集性。结论湖州属戊型肝炎高流行区,感染率随年龄增长而升高,且存在大量亚临床感染。

Objective The present investigation was conducted to gain insight into the seroepidemiological characteristics and the infection rate of hepatitis E among the natural population in Huzhou city. Methods The Huzhou City is divided as three parts, which are plain water villages, mountain areas and towns, and 1666 people were randomly selected as participants from the whole population in Huzhou City. ELISA methods were used to test the HEVIgG antibody of hepatitis E in the serum and investigate relevant risk factors at the same time. Results 749 participants were found to be positive for HEV-IgG antibody, with the total infection rate of HEV being 44.96%, and the standardized infec- tion rate 38.88%. The infection rate of HEV was significantly higher in towns and plain water villages than in mountain areas. The rate increased with age, with a family predisposition for the disease perceived. Conclusion The infection rate of hepatitis E is high in Huzhou City, which increases with age, and there are many cases of sub-clinicalinfection.