米非司酮配伍米索前列醇终止中期妊娠引产110例临床观察

Clinical observation on mifepriston in combination mifeprostol terminating 110 cases intermediate pregnancy

目的探讨对14～27周妊娠两种不同引产方法的效果。方法将110例妊娠14～27周自愿要求终止妊娠者随机分成雷佛努尔组、米非司酮联合米索前列醇组，观察两组的总产程时间，产后2h出血量，胎盘、胎膜残留情况，产伤情况，引产成功例数等情况。结果对于14～27周中期妊娠者，米非司酮联合米索前列醇，较单独用雷佛努尔引产总产程时间短，产后2h出血量少，胎盘、胎膜残留率低，两种引产引产成功率差异无显著性。结论对于14～27周中期妊娠者，使用米非司酮配伍米索前列醇引产，可缩短引产时间，减少产后出血量，降低胎盘、胎膜残留率，临床上值得推广。

Objective To investigate the effect of two different methods for 14 - 27 weeks pregnancy abortion. Methods Two hundreds and twenty women who had 14 - 27 weeks pregnancy and asked for abortion were divided into two growps randomly. 110 cases took mifepriston in combination mifeprostol. 110 cases used ethacridine Observe the total stage of labor , the amount of 2 hours＇s postpartum hemorrhage, the remained rates of placentafetal and membrane and the success cases in the two groups. Results Women the total stage of labor in the mifepriston in combination mifeprostol group was shorter than that of ethacridine group. The amount of 2 hours＇ postpartum hemorrhage , the remained rates of placentafetal and membrane in the mifepriston in combination mifeprostol group were all significiantly lower than that in the ethacridine group. The success rate between the two groups was no difference . Conclusions Mifepriston in combination mifeprostol is effective and safe to terminate intermediate pregnancy.