4Masubuchi Y.Metabolic and non-metabolic factors determining troglitazone hepatotoxicity[J].Drug Metab Pharmacokinet,2006,21(5):347
5Neuschwander-Tetri BA,Brunt EM,Wehmeier KR,et al.Improved non-alcoholic steatohepatitis after 48 weeks of treatment with the PPAR2-gamma ligand rosiglitazone[J].Hepatology,2003,10:1008
8Angulo P.Use of ursodeoxycholic acid in patients with liver disease[J].Curr Gastroenterol Rep,2002,4:37
9Santos VN,Lanzoni VP,Szejnfeld J,et al.A randomized doubleblind study of the short-time treament of obese patiens with nonalcoholic fatty liver disease with ursodeoxycholic acid[J].Braz J Med Biol Res,2003,36:723
10Lukivskaya O,Zavodnik L,Knas M,et al.Antioxidant mechanism of hepatoprotection by ursodeoxycholic acid in experimental alcoholic steatohepatitis[J].Adv Med Sci,2006,51:54
4[1]Knodell RG,Isha KG,Black WC,et al.fomulation and application of a numerical sooring system for assessing histological activity in asymptomatic chronic active hepatis.Heptology,1981,1:431-435
5[2]Chevallier M,Guerrt S,Chossegros P,et al.A histological semiquan titative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens:comparison with morphometric studies.Heptology,1994,20:349-355
6[3]Gressner AM,Bachem MG.Molecular mechanisms of fibrogenesisA homage to the role of activated fat-storing cells.Digestion,1995,56:335-346
7Zhang Y, Proence R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue[J]. Nature,1994,372:425.
8Campfield LA, Smith F, Gulsez Y, et al. Recombiant mouse OB protein: evidence for a peripheral signal linking adipocity and central networks [J ]. Science, 1995, 269 :1546.
9Grill, Harvey J. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake[J]. Endocrinology, 2002,143( 1 ) : 239.
10Cao XP. Effects of acute of prolonged exposure to leptin on hepatic glucose oxidation[J]. Chin Med J, 2001,114(6):592.
8Laurin J, Lindor KD, Crippin JS. Ursodeoxycholicacid or clofibrate in the treatment of non - alcohol - induced steatohepatitis: a pilot study [ J]. Hepatology, 1996,23 (6) : 1464 - 1467.
9Browning J,Szczepaniak L,Dobbins R,et al.Prevalence of hepatic steatosis in an urban population in the United States:impact of ethnicity.Hepatology,2004,40:1387-1395.
