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Richter’s综合征的克隆相关性分析 被引量：1

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摘要 目的分析Richter’s综合征中B-CLL/DLBCL两种肿瘤IGVH基因克隆重排及突变状态,分析其克隆相关性,初步探讨可能涉及的分子机制。方法用PCR及基因扫描(GeneScan)分析IGVH基因的克隆性重排;用克隆测序检测和分析两种肿瘤的克隆相关性及IGVH基因的突变状态;用免疫组化染色的方法检测两种肿瘤中ZAP70和p53的表达。结果(1)基因扫描发现该例Richter’s综合征中B-CLL和DLBCL两种肿瘤的IGVH基因均为单克隆重排且重排片段长度一致;(2)克隆测序证实两种肿瘤携带相同的未突变IGVH3-74基因;(3)该例Richter’s转化的DLBCL不表达CD5和CD23;ZAP70,p53和Kappa在B-CLL及DLBCL均阳性。结论该例Richter’s转化的DLBCL由克隆相关的携带未突变型IGVH基因的B-CLL患者转化而来,p53可能在转化过程起一定作用。
作者 毛峥嵘 Andreas Rosenwald 章锁江 周韧 H K Mueller-Hermelink
机构地区 浙江大学病理学研究所 Pathology Institute
出处 《实用肿瘤杂志》 CAS 2007年第2期145-149,共5页 Journal of Practical Oncology
基金 国家留学基金委员会(China Scholarship Council)(批准号:20033008) 德国Hanns-Seidel Stiftung基金 浙江省自然科学基金(Y205292)资助
关键词 白血病 粒细胞 慢性 基因重排 克隆 分子 基因表达谱 免疫球蛋白 重链/生物合成 免疫球蛋白 可变区/遗传学 淋巴瘤 B细胞
分类号 R733.7 [医药卫生—肿瘤]
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参考文献19

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同被引文献13

  • 1何春年,徐翠清,赵焕芬,翟金萍.变异型Richter综合征1例并文献复习[J].新医学,2005,36(9):519-520. 被引量：2
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实用肿瘤杂志
2007年 第2期

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