肝细胞癌中潜伏膜蛋白-1的表达及意义

Expression and Significance of Latent Membrane Protein-1 in Hepatocellular Carcinoma

目的 探讨EB病毒潜伏膜蛋白-1（LMP1）在肝细胞癌（HCC）中的表达及意义.方法 应用免疫组织化学SP法,对石蜡包埋的50例HCC组织（HCC组）和10例正常肝组织（对照组）标本检测LMP1的表达.结果 （1）LMP1阳性表达率HCC癌组织（38%）和癌旁肝硬化组织（38.9%）均高于癌旁非肝硬化组织和正常对照组（均为0,P＜0.05）;（2）HCC癌组织中LMP1阳性表达率在Ⅲ～Ⅳ（51.7%）高于Ⅰ～Ⅱ期（19.0%,P＜0.05）,有门静脉癌栓形成（50%）高于无门静脉癌栓形成（16.7%,P＜0.05）.结论 EB病毒LMP1与HCC病期进展及有无门静脉癌栓形成密切相关,可作为估计HCC患者预后的参考指标.

Objective To explore the expression and significance of latent membrane protein-1 （LMP1） in hepatocellular carcinoma（HCC）. Methods 50 cases of HCC as examined group and 10 cases of normal liver tissues as control group were examined for LMP1 expression with SP immunohistochemistry. Results （1）The positive expression rate of LMP1 in HCC（38%） and pericarcinomatous hepatic cirrhosis（38.9%） were significantly higher than that in pericarcinomatous non-hepatic cirrhosis and normal liver tissues（both 0, P〈0. 05）. （2）In HCC, the positive expression rate of LMP1 in Ⅲ-Ⅳ phase （51.7%） was higher than that in Ⅰ -Ⅱ phase（19.0%, P〈0.05）. It was higher in cases with portal vein tumor embolus（50% ） than that in cases without（16. 7%, P〈0.05）. LMP1 had a close relation with TNM stage also. Conclusion LMP1 can be used as a helpful index to predict the patients＇ prognosis.