摘要
目的 以阿司匹林为药物模型,制备阿司匹林磁性壳聚糖微球(AMCM),研究其体外释放度与体内靶向性.方法 利用壳聚糖为骨架材料,以Fe3O4作为磁性内核,戊二醛作为交联剂,固载阿司匹林,研制AMCM,采用动态透析法及分光光度法进行体外释药实验;设定纯种兔为一靶区,外加磁场,经兔耳缘静脉注射AMCM,观察AMCM在体内分布情况,并观察外加磁场强度对微球在靶区定位的影响.结果 制备的AMCM成球性能好,无粘连,粒径1~8 μm,载药率0.922(W/W),包封率82.4%,具有显著的缓释阿司匹林作用,经外加磁场下的AMCM有较好的靶向分布性且与磁场强度相平行.结论 自制的AMCM具有显著的体外缓释与体内靶向作用.
Objective To prepare aspirin magnetically chitosan microspheres (AMCM) and investigate AMCM releasing rate in vitro and in vivo. Methods This experiment adopts Fe2O3 as mangnetic. This experiment adopts dynamic dialysis and ultraviolet spectrometer to release drug in vivo. AMCM injected directly into purebred rabbit. distribution of AMCM and targeting index under encompassing magnet was monitored. Results 1-8μm diameter AMCM could easily made and have no adherence. And its also show AMCM has 0.922(W/W) of loading rate, 82.4% of enveloping rate, and AMCM was a slowly releasing-drug. Under encompassing magnet, AMCM has good targeting distribution and parallel to magnetic density.Conclusion AMCM is a new method for aspirin targeting in vivo.
出处
《福建医科大学学报》
2007年第2期179-181,共3页
Journal of Fujian Medical University
关键词
阿司匹林
壳聚糖
胶囊
迟效制剂
微球体
aspirin
chitosan
capsules
delayed-action preparations
microspheres