中老年男性骨密度的影响因素及相关性分析

Effect Factors and Relativity Analysis of Bone Mineral Density in Middle-aged and Aged Men

目的:探讨中国天津地区中老年男性骨密度的影响因素。方法:用双能X线吸收测量法测量82例中老年男性(47～75岁)腰椎2～4骨密度和全身骨密度,并用放免法检测血清激素水平。结果:校正年龄和体质量指数后,骨密度与睾酮(P<0.01)、雌二醇(P<0.05)呈正相关,与瘦素(P<0.05)呈负相关,与胰岛素无关。多元线性回归分析,仅年龄、体质量指数、瘦素与骨密度相关。结论:中老年男性的瘦素是影响骨密度的主要因素,并推测瘦素与骨密度的相关性可能较性激素更强。

Objective： To investigate the effect factors of bone mineral density （BMD） in middle-aged and aged men in Tianjin China. Methods： BMD at lumber spine 2-4 and total bone were measured by DXA and the serum hormone concentration was measured by RIA in 82 （47-75） middle-aged and aged men. Results： BMD positively correlated to testosterone （P 〈 0.01） and estradinl （P 〈 0.05）, negatively correlated to leptin （P 〈 0.05）, and no significant difference between BMD and insulin after controlling for age and body mass index. Only age, BMI and leptin correlated to BMD by multiple regression analysis. Conclusion： Leptin is a main effect factor of BMD in middle-aged and aged men, and it may be more correlated to BMD than sex hormones.