胃液癌胚抗原测定在某些胃部疾病诊断中的价值分析

Analysis of effect of carcino-embryonic antigen（CEA） asssy on diagnosing gastric diseases

目的探讨胃液中癌胚抗原（CEA）在5种胃部疾病中的变化。方法采用放射免疫法测定某些胃部疾病患者的血液及胃液中的CEA水平，并相互比较。结果萎缩性胃炎与胃癌2组血液中CEA水平与其他3组比较差异无统计学意义（P〉0．05），而两组胃液CEA水平比较差异有统计学意义（P〈0．01），胃癌胃液中CEA水平与分化程度密切相关，但与形状和大小无关。结论胃液中CEA水平测定对于临床诊断某些胃部疾病及判断肿瘤预后有一定的参考价值。

Objective To explore changes of CEA in gastric juice of patients with 5 different kinds of gastric diseases respectively and to evaluate the role of CEA in diagnosing gastric diseases. Methods Radioimmunoassay was used to measur levels of CEA in blood and gastric juice of patients with gastric diseases. Results Neither levels of CEA in blood of patients in atrophic gastritis group nor those in gastic carcinoma groups was significantly different from those in the other three groups （ P 〉 0.05 ）, while levels of CEA in gastric juice of patients in the two groups were significantly higher than those of the other three groups （ P 〈 0. 01 ）. The level of CEA in gastric juice was closely related to the differentiation level of gastric carcinoma,but not to figure and size of it. Conclusions CEA level in gastric juice is of diagnostic value for patients with gastric diseases.