凋亡抑制因子Survivin在膀胱癌中的表达与CPA血流的相关性研究

Survivin expression in bladder carcinoma and its relationship to the blood flow of CPA

目的:探讨膀胱癌中凋亡抑制因子Survivin的表达与CPA血流的关系。方法:术前应用CPA检测50例膀胱癌患者及20例膀胱非肿瘤性增生患者的血流信号及其阻力指数RI,术后用免疫组化法测该组织中Survivin基因蛋白的表达。结果:50例膀胱癌患者的Survivin基因蛋白的阳性表达率(78%)显著高于非肿瘤性增生组(25%,P<0.05)。膀胱癌的Survivin基因蛋白的表达强度与CPA血流分级呈正相关(r=0.699,P<0.05),其RI值(0.50±0.43)明显低于非肿瘤性增生组(0.69±0.41,P<0.05),表达强度与RI值呈负相关(r=-0.545,P<0.05)。结论:Survivin基因蛋白在膀胱癌中呈高强度表达,其表达强度与CPA的血流分级呈正相关。两者的有机结合可在术前、术后对膀胱癌进行评估并为临床早期诊断及判断预后提供新的理论依据。

Objective： To evaluate the relationship between the expression of Survivin gene protein and the blood flow of color power Doppler angio imaging （CPA） in bladder carcinoma. Methods： Fifty patients of bladder carcinoma and 20 cases of hyperplasia were examined preoperatively by CPA whereas Survivin gene protein was stained immunohistochemistry after operation. Results： The positive expression ratio of Survivin gene protein in 50 cases of bladder carcinoma （78%） was significant higher than that of the hyperplasia group（25%, P〈0.05）. The expression intensity of Survivin gene in the group of bladder carcinoma correlated positively to the degreens of their CPA（r=0.699, P〈0.05）. The resistance index（RI） value of malignant group （0.50±0.43） was slight lower than that of the hyperplasia group （0.69±0.41, P〈0.05）. In addition, the expression intensity of Survivin gene in the group of bladder carcinoma correlated negatively to their RI values （r=-0.545, P〈0.05）. Conclusion： The high expression of Survivin gene was widely observed in bladder carcinoma, and its expression intensity correlated positively to the RI values. The combination of Survivin gene and CPA can help us to assess the bladder carcinoma before and after operation. Furthermore, it may provide important information for earlier clinical diagnosis and judgment of prognosis.