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CDK9/Cyclin T(P-TEFb)及其生物学功能 被引量：3

CDK9/CyclinT(P-TEFb) and Its Biological Functions
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摘要 细胞周期依赖性激酶（cyclin-dependentkinases，CDKs）家族目前已经发现9个成员（CDK1～CDK9），根据其功能分为两大类：控制细胞周期的CDKs和控制细胞转录的CDKs。CDK9即属于后者。CDK9是正性转录延长因子b（positive transcription elongation factorb，P-TEFb）中的催化亚基成分，通过磷酸化RNA聚合酶Ⅱ（RNA polymeraseⅡ）和一些负性转录延长因子从而使转录从起始部位得以延伸。cdk9／cyclin T的异常表达与很多疾病的发生有密切关系。Cdk9／CyclinT将给艾滋病和肿瘤等疾病的治疗提供颇有应用前景的作用靶点。 Nine members of the cyclin-dependent kinases （CDKs） have been identified so far. The family members of CDKs can be further divided into two major functional groups in terms of their roles in cell cycle or transcriptional control. CDK9 belongs to the group of transcriptional control. CDK9 is the catalyzing subunit of positive-transcription elongation factors b （P-TEFb） , which catalyzes the transcriptional elongation by phosphorylating RNA polymerase Ⅱ （RNA pol Ⅱ）, as well as some negative elongation factors. The abnormal expression of CDK9/CyclinT is highly correlated with the development of many diseases. CDK9/CyclinT may serve as a target for the treatment of AIDS and tumors.
作者 曹华 高瀛岱
机构地区 中国医学科学院
出处 《医学分子生物学杂志》 CAS CSCD 2007年第2期161-163,共3页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No30400558) 天津市科技攻关计划培育项目(No05YFGPGX06900)~~
关键词 细胞周期依赖性蛋白9 CDK9 正性转录延长因子b RNA聚合酶Ⅱ cyclin-dependent kinase 9 positive transcription elongation factor b RNA poly-merase Ⅱ
分类号 R734.2 [医药卫生—肿瘤]
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参考文献24

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同被引文献44

  • 1王世鄂,黄威权,孙岚,吕葆真.PeroxiredoxinⅡ在小鼠早胚发育中的作用及机理[J].解剖学报,2005,36(3):300-302. 被引量：5
  • 2GARRIGA J, GRANA X. Cellular control of gene expression by T- type cyclin/CDK9 complexes[J]. Gene, 2004, 337: 15-23.
  • 3RAMAKRISHNAN R, YU W, RICE A P. Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1 [ J]. BMC Res Notes, 2011, 4: 260.
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  • 6VISUDTIPHOLE V, KLINBUNGA S, KIRTIKARA K. Molecular characterization and expression profiles of cyclin A and cyclin B during ovarian development of the giant tiger shrimp Penaeus monodon[J].Comp Biochem Physiol A, 2009, 152(4) : 535-543.
  • 7HAN K, DAI Y, ZOU Z, et al. Molecular characterization and expression profiles of cdc2 and eyelin B during oogenesis and sper- matogenesis in green mud crab (Scylla paramamosain) [ J]. Comp Biochem Physiol B, 2012, 163(3/4) : 292-302.
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  • 9MANCHBO H Y, LEE G, FLYGARE J, et al. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro [J]. Genes Bey, 1997, 11(20): 2633-2644.
  • 10ZHANG H S, WU M R. SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase [J]. Virus Res, 2009, 146(1/2) : 51-57.

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医学分子生物学杂志
2007年 第2期

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