眼附属器黏膜相关淋巴组织淋巴瘤的研究进展

Progress of the molecular genetics of ocular adnexal mucosa-associated lymphoid tissue lymphoma

黏膜相关淋巴组织(MALT)淋巴瘤是非霍奇金淋巴瘤中结外边缘带淋巴瘤(MZL)的一种特殊类型。眼附属器MALT淋巴瘤是眼眶恶性肿瘤中较常见的一种,可发生在结膜、泪腺、眼睑和眼眶。近年来,国外许多学者在MALT淋巴瘤的临床特点、病理形态学、免疫表型、分子遗传学及分子生物学方面对它的发生机制在基因水平有了新的认识。就国外对眼附属器MALT淋巴瘤的分子遗传学异常在肿瘤细胞内部信号转导通路中作用的研究做一综述。

The mucosa-associated lymphoid tissue （MALT） lymphoma represents a distinct subgroup of B-cell non-Hodgkin lymphoma（NHL） as arising from extranodal sites. Ocular adnexal MALT lymphoma occurs in the conjunctiva, eyelids,lacrimal gland and orbit. The lymphoepithelial lesions formed for invasion of individual mucosal glands or other epithelial structures by aggregating lymphoma cells. The pathogenesis of ocular adnexal MALT lymphoma is based on the new understating of the studied in clinical, morphology,immunology and molecular genetics. The genetic abnormalities reported to occur in mucosa-associated lymphoid tissue （MALT） lymphomas are the three genes translocations： t（11;18）（q21;q21）,t（1;14）（p22;q32） and t（14;18）（q32;q21）,and the aberrant genes appear to be specific for, or at least closely related to this type of B-cell non-Hodgkin＇ s lymphoma, These translocations of genes further affect the expression of MALT1 （ 18q21 ） and BCL10 （1p22） genes. The research progress of MALT lymphoma and molecular events that link the genetic abnormalities to etiology are reviewed.