可溶性细胞间黏附分子-1在多囊卵巢综合征的研究

Study of Serum Soluable Intercellur Adhension Molecule-1 in Polycystic Ovarian Syndrome

目的探讨多囊卵巢综合征(pcos)患者中的可溶性细胞间黏附分子-1(sICAM-1)水平及其临床意义。方法采用酶联免疫吸附法(ELISA)对41例多囊卵巢综合征患者及39名健康人的血清sICAM-1水平进行检测,并与临床指标进行多元线性回归分析。结果①多囊卵巢综合征患者的血清sICAM-1水平高于正常人(P<0.01);②BMI≥25kg/m2的血清sI-CAM-1浓度比BMI<25kg/m2水平明显升高(P<0.01);③腰臀比(WHR)≥0.8的血清sICAM-1的浓度比腰臀比<0.8的明显升高(P<0.01);④多元线性回归分析显示多囊卵巢综合征患者的血清sICAM-1水平与年龄、BMI、腰臀比成正相关,与血清雌二醇的浓度成负相关。结论sICAM-1与PCOS可能有密切的关系,随着年龄越大,腰臀比及体重指数增大,sICAM-1水平渐增。

Objective To investigate plasma soluble intercellular adhesion molecule - 1 （ sICAM - 1 ） concentration in women with polycystic ovary syndrome （pcos） and their clinic significance. Methods The level of sICAM - 1 in serum in 41 patients with pcos and in 39 healthy persons were measured by ELASA. The possible relationship between sICAM - 1 and clinical materials were analyzed by multiple linear regression analysis. Results ①The sICAM - 1 level in women with PCOS was higher than of that healthy persons （ P 〈 0.01 ） ; ②The level of slCAM - 1 in serum in women with BMI≥25kg/m^2 was higher than of women with BMI 〈 25kg/m^2 （P 〈 0. 01 ） ;③the level of sICAM - 1 in serum in women with waist - to - hipratio（WHR） ~0.8 was higher than that of women with WHR 〈 0.8 （P 〈 0.01 ） ;④ Multiple linear regression analysis showed that the level sICAM - 1 in women with pcos was correlated positively with age, BMI, and waist - to - hipratio but correlated inversely with E2. Conclusions sICAM - 1 was prossibly associatied with PCOS. The sICAM - 1 level was correlated positively with the age ,WHR and BMI.