空腹血糖受损诊断标准下调对内皮功能的影响

The Effect of Down Regulation of Fast Glucose Damge Standard on Endothelial Function

目的探讨空腹血糖受损诊断标准下调后对内皮功能的影响。方法对54101名正常体检者进行空腹血糖(FBG)、血脂、尿酸的检测,并根据FBG水平分为A组FBG<5.6mmol/L,B组FBG≥5.6mmol/L且FBG<6.1mmol/L,C组FBG≥6.1mmol/L同时FBG<7.0mmol/L,D组FBG≥7.0mmol/L,B组为新增人群,TC、TG、尿酸高于A组,低于C组。在上述人群中采用随机方法选择655名,同时进行餐后2h血糖(PBG)、空腹胰岛素(FINS)、餐后胰岛素(PINS),内皮素(ET)、一氧化氮(NO)等。此655名人群同时进行血流介导的内皮依赖性血管扩张(EDD)和硝酸甘油(NGT)介导的非内皮依赖性血管扩张。进行组间比较。结果新增人群在EDD中已明显低于FBG<5.6mmol/L(A组),但与C、D组比较,差异无统计学意义;NGT介导的非内皮依赖性血管扩张B组高于C组,C组低于A组,其余两两比较,差异无统计学意义。结论空腹血糖受损诊断标准下调新增人群在内皮功能上已有变化。

Objective To approach the effect of down regulation of fast glucose damge standard on endothelial funtion. Methods The FBS ,serum lipid, uric acid of 54101 normal subjects were detected, those subjects were divided by FBG value into four groups： A B C D ,the value of TC, TG. uric acid in group B were higher than which in group A, lower than in group C. The value of PBG.FINS, PINS,ET.NO of 655 subjects ehoieed randomly were detected . At the same time the endodermis dependence angieetasia funtion mediated by bloodstream and the no - endodermis dependence angiectasia funtion mediated by glycerol trinitrate were detected . Results The value of group B was lower than which in group A, having no statistical meanings compared with group C, D ; the no - endodermis dependence angieetasia funtion mediated by glycerol trinitrate of group B was higher than that of group C, that of group C was lower than group A, the comparison of other two groups has no statistical meanings. Conclusions Down regulation of fast glucose damge standard can effect on the endothelial funtion.