血清瘦素(leptin)水平检测在肝硬化中的临床意义

Study of significance of leptin level in cirrhosis

[目的]通过检测不同分级肝硬化患者血清leptin水平,探讨leptin检测在肝硬化中的临床意义。[方法]用ELISA法检测59例肝硬化患者及70名健康对照者的血清leptin水平,对肝硬化患者进行Ch ild-Pugh分级,并测定全部受试者身高、体重,计算其体重指数(BM I)。[结果]肝硬化患者血清leptin水平(13.55±4.59)ng/mL显著高于正常对照组(7.33±3.37)ng/mL(P<0.01),女性肝硬化患者血清leptin水平(17.87±4.86)ng/mL显著高于男性患者(11.65±3.83)ng/mL(P<0.05),不同分级肝硬化三组间血清leptin均值(12.44±4.88)ng/mL、(14.09±5.12)ng/mL和(14.99±4.97)ng/mL之间差异无显著意义(P>0.05)。[结论]肝硬化患者血清leptin水平高于正常人,并有性别差异,但leptin水平与肝硬化分级无明显相关。

[ Objective] To study and analyze the levels of serum leptin in healthy volunteers, patients with cirrhosis. [ Methods] A ELISA was used to test leptin in human serum include 59 patients with cirrhosis and 70 healthy volunteers. [ Results] Leptin level in healthy volunteers [ （7.33 ± 3.37）ng/mL] had a statistical difference with that of patients with cirrhosis（ 13.55 ± 4.59 ）ng/mL（ P 〈 0. O1 ）,but there was no statistical difference in different Child- Pugh class of cirrhosis（ 12.44 ± 4.88 ）ng/mL, （14.09 ± 5.12）ng/ mLand （ 14.99 ± 4.97） ng/mL（ P 〉 0. 05 ）. And leptin level in cirrhosis had a statistical difference between male（ 17.87 ± 4.86 ） ng/ roLand female [ （ 11.65 ± 3.83 ） ] ng/mL（ P 〈 0. 05 ）. [ Conclusions ] There is a statistical difference of leptin levels in healthy volunteers and patients with cirrhosis. And leptin level also is a correlation with gender. But there is no statistical difference of leptin levels in different Child - Pugh class of cirrhosis.