P—PDGFR—α在胃肠道间质瘤和胃肠道外间质瘤的表达及其临床意义

The expression and clinical significance of p - PDGFR - α in gastrointestinal stromal tumors and extra- gastrointestinal stromal tumors

目的探讨磷酸化血小板源性生长因子受体α（P—PDGFR—α）在胃肠道间质瘤（GIST）和胃肠道外间质瘤（EGIST）的表达及临床意义，为进一步提高GIST的病理诊断、病理分型，及临床治疗提供有力的依据。方法用免疫组织化学方法（Envision）检测GIST中P-PDGFR—α的表达。结果P—PDGFR—α在CD117阴性的GIST表达显著高于在CD117阳性的GIST表达（P〈0．05）；P—PDGFR—α在上皮型和混合型的GIST表达均显著高于在梭型细胞型GIST的表达（P〈0．05）；CD117在梭型细胞型GIST的表达明显高于在上皮型和混合型GIST的表达（P〈0．05）。结论P—PDGFR—α对CD117阴性的GIST的病理诊断、病理分型和临床治疗进一步提供了可靠的依据。PDGFR—α基因突变后引起产物蛋白的磷酸化，可能是CD117阴性的GIST发生的重要分子基础和生物学行为。

Objective To explore the expression and clinical significance of phosphor - platelet derived growth factor receptor alpha （p- PDGFR -α） in gastrointestinal stromal tumors and extra- gastrointestinal stromal tumors, providing reliable evidence for further improvement of the pathological diagnosis, pathological typing and the clinical treatment of GIST, Methods The expression of p - PDGFR - α was detected with the method of envision immunohistochemical staining, Result The expression of p - PDGFR - α in the GISTs that were negative for CD117 is significantly higher than that in CD117 positive GISTs （ P 〈 0. 05 ）. The expression of p -PDGFR -α in epithelioid GISTs and mixed GISTs both are significantly higher than that in fusiform GISTs （ P 〈0.05）, The expression of CD117 in fusiform GISTs is significant higher than that in epithelioid GISTs and mixed GISTs （ P 〈 0. 05 ）. Conclusions p - PDGFR - α detection can provide reliable evidence for the further improvement of the pathological diagnosis, pathological typing and the clinical treatment of GISTs that were CD117 negative. PDGFR -otmutations might induce protein phosphorylation, which may be the important alternative molecular mechanism and biological behavior for the development of GISTs that were CD117 negative.