早期行保存板层角巩膜联合干细胞移植治疗眼严重碱烧伤的临床观察

Early preserve lameller corneoscleral transplant uniting with corneal limbal stem cell allograft in treating severe ocular surface alkali burns

目的评价早期行保存板层角巩膜移植联合干细胞移植治疗眼严重碱烧伤的疗效。方法将符合Roper-Hall诊断标准Ⅲ～Ⅳ度的眼部碱烧伤患者共28例32眼在受伤二周内行保存板层角巩膜移植联合干细胞移植术。结果随访3～36个月,术后视力提高者18眼（56.2%,18/32）,未提高者10眼,下降者4眼。角膜植片透明14眼,透明率43.7%（14/32）。无一眼发生角膜溃疡穿孔。结论对眼严重碱烧伤的患者行早期清创合并保存板层角巩膜移植联合干细胞移植术,可有效减少角膜溃疡穿孔、角膜血管化,提高视力。

Objective To evaluate the effect of early preserve lameller corneoscleral transplantation uniting with corneal limbal stem cell allograft treating severe ocular surface alkali burn. Methods The patients compatible with the Ⅲ or IV grades of Rober-Halls were 28 cases and 32 eyes, they treated by early preserve lameller corneoscleral transplantation uniting with corneal limbal stem cell allograft in two weeks. Result During the following-up of 3-36 months, 18 of 32 eyes with preserve lameller corneoscleral transplantation had significantly improved vision, and 10 eyes had not improved, and 4 eyes had descended. Corneal cure rate was 43.7% （14/32）. No perforation occurration in any case. Conclusion The method of early preserve lameller corneosclerel transplantation uniting with corneal limbal stem cell allograft was effectived in treating severe ocular surface alkali bum, and decreased the occurrence of corneal perforation ,corneal neovascularization, and improve visual acuity.