莫西沙星治疗泌尿生殖系统感染的安全性与经济学评价

On Safety and Pharmacoeconomics of Moxifloxacin in the Management of Urinogenital Infection

目的:观察莫西沙星治疗泌尿生殖系统感染的临床疗效和安全性,并进行药物经济学评价。方法:将76例泌尿生殖系统感染患者分为两组,其中膀胱炎22例,肾盂肾炎12例,前列腺炎16例,副睾炎5例,淋球菌性尿道炎15例,其他尿路感染6例。A组(治疗组)38例,男26例,女12例,年龄(45±13)岁,给予莫西沙星片400mg,po,qd,7d;B组(对照组)38例,男25例,女13例,年龄(45±12)岁,给予加替沙星0.2g,ivgtt,bid,7d。观察两组临床疗效,细菌学清除率及不良反应,并对两种方案采用药物经济学中最小成本分析法进行分析。结果:治疗组治疗后,总有效率86.8%(33/38),细菌学清除率91.3%(42/46),不良反应发生率2.63%(1/38);对照组总有效率89.5%(34/38),细菌学清除率92.0%(46/50),不良反应发生率5.26%(2/38),2组比较差异无显著性(P>0.05),但A组的医疗费用却明显低于B组(P<0.01)。结论:对泌尿生殖系统感染的患者,采用莫西沙星口服治疗,不但安全、有效,而且更加经济合理。

OBJECTIVE： To observe the clinical efficacy and safety of moxifloxacin in the management of urinogenital infection and to conduct pharmacoeconomical analysis of this drug. METHODS： A total of 76 cases with urinogenital infections were enrolled （of which, 22 were patients with cystitis, 16 were with pyelonephritis, 12 were with prostatitis, 5 were with epididymis, 15 were with gonococcal urethritis and 6 were with other urinary tract infections）： 38 （treatment group, ratio of male to female： 26 vs. 12, aged at 45 13） were assigned to receive Moxifloxacin tablets 400 mg peros q.d. for 7 days, another 38 （control group, ratio of male to female： 25 vs. 13, aged at 45 12） to receive Gatifloxacin 0.2g iv gtt b. i.d. for 7 days. The 2 groups were observed with regard to clinical efficacy, bacteria clearance and adverse reactions ; meanwhile, a cost - minimization analysis was performed on the 2 groups. RESULTS： The total response rates, bacteria clearance rates and incidences of adverse reaction in treatment group vs. in control group were 86.8% （33/38） vs. 89.5% （34/38）, 91.3% （42/46） vs. 92.0% （46/50） and 2.63% （1/38） vs. 5.26% （2/38）, respectively, showing no significance between the 2 groups （ P 〉 0.05）, but the medical fee in treatment group was significantly lower than in control group B （ P 〈 0.01 ）. CONCLUSION ： For patients with urinogenital infection, oral administration of moxiloxacin is not only safe and effective, but also more economical and reasonable.