低分子肝素治疗急性脑梗塞的疗效及安全性研究

Research on the curative effects and safety of using low molecular heparin to treat acute cerebral infarction

目的探讨低分子肝素治疗急性脑梗塞患者的临床疗效及安全性。方法72例脑梗塞的患者随机分为治疗组(37例)和对照组(35例),两组均个体化治疗。治疗组在此基础上应用低分子肝素,连续用10d;治疗前后进行神经功能缺损评分并评价疗效,监测纤维蛋白原(Fg)、凝血酶原时间(PT)、血小板粘附率、出血时间(BT)、凝血时间(CT)、部分凝血活酶时间(KPTT),并与对照组比较。结果治疗组总有效率91.9%,明显高于对照组80%(P<0.05);Fg降低,PT延长,BPC粘附率降低较治疗前有显著差异(P<0.01);较对照组也有显著差异(P<0.01);CT、BT、KPTT治疗前后、与对照组治疗后相比较无显著差异。结论低分子肝素具有抗凝溶栓作用,对急性脑梗塞患者的神经功能缺损有明显恢复,且无再出血的危险及严重的不良反应,治疗脑梗塞有效、安全。

Objective To research into the curative effects and safety of using low molecular heparin to treat acute cerebral infarction. Methods 72 correspondent patients were divided into two groups, namely the experimented group （37） and the other（35） to serve as contrast. Both the two groups were given independent treatment, The experimented group is appplied to molecular heparin on the basis, with the period lasting 10 days. In addition, the impairment of nerve function was also evaluated before and after treatment, which acted as a means of judge of the curative effects. The experimented group was monitored in the following aspects： Fg, PT, BPC, BT, CT, KPTT, and compared with the contrst group. Result The experimented group had an obvious improvement after the treatment, with the efficiency amounting to 91, 9%, having a absolute advantage over the contrast group , whose efficiency was only 80% （ P 〈 0.01 ）. Fg was reduced while PT was extended, and BPC saw an evident difference from before treatment. （P 〈 0.01 ）. CT, BT, KPTT were not much different from the contrast group. Conclusion Low molecular heparin is effective in resisting congealing and dissolving embolism, thus helping the recovery of impairment of nerve function of patients suffering from acute cerebral infarction. There is no more danger of bleeding and no severe harmful effects. The medicine to cure brain block is safe and effective.