血清α_1-抗胰蛋白酶检测对多种恶性肿瘤的诊断价值

The diagnosis value of the determination of serum Alpha-1-antitrypsin of lung and varied digestive cancers

作者对测定血清α1-抗胰蛋白酶（α1－AT）常用的胰酶活性抑制法和免疫电泳法进行了比较，并用两法同时测定了肺癌及非癌性肺疾病和肝癌、胰腺癌等五种消化系统恶性肿瘤患者血清α－AT含量。结果显示，肺癌及非癌性疾病组血清α－AT水平均显著高于正常对照组（P＜0．001），肺癌组明显高于非癌性肺病组（P＜0．05）；测定各消化系统肿瘤组血清α1－AT含量均明显比对照组升高（P＜0．001）。结果表明恶性肿瘤发生时，α1－AT作为急性相反应物可非特异性上升，高于非癌性疾病，对恶性肿瘤的诊断及鉴别有一定临床价值。两种测定方法相比免疫电泳法为较好的临床血清α1－AT测定法。

In this experiment we compare two test emthods to determine the serum alpha1-antitrypsin (a1-AT ) level, the enzymatic and immunoelectrophoresis methods. With the both methods we measure the a1-AT concentration in the serum of neoplastic and non-neoplastic lung diseases and varied digestive cancers including hepatic, pancreatic, esophageal cancers. The results from both test methods give identical finding, which indicate that the serum a1-AT level of lung cancer is significantly higher than that of normal contro(P＜0. 001) and it is also higher than that of non-neoplastic lung diseases according to only immunological method (P＜0. 05). The serum a1-AT level of all determined five sorts of digestive cancers are higher than that of normal control nonspecific1y (P＜0. 001). The results show that, as a sort of acut phase reactants, serum a1-AT level may elevate in varied cancers nonspecificly, and may be higher than that of non-neoplastic disease so it may have clinical meaning for diagnosis or screen of these cancers. Comparing the both test methods of serum a1-AT we think the immunoelectrophoresis method may be better selection for clinical usage.