脱钙骨/聚乳酸重组人工骨的研制及其相关性能检测

Development of composited artificial bone made from demineralized bone and polylactic acid and property assessment

目的研制性能优良的人工骨材料并评价其相关性能。方法将脱钙骨、聚乳酸、氯化钠按比例复合,利用模压增强法制备重组人工骨(BPCB)材料,检测其孔隙率、孔径、生物力学强度等性能参数,并与有机溶剂注模颗粒沥滤法制备的材料进行比较。结果研制的BPCB材料孔隙率为55.20%、孔径为227.33μm、压缩强度为5.52MPa、弯曲强度为19.61MPa。与有机溶剂注模颗粒沥滤法相比,模压增强法制备的材料强度更高。结论BPCB材料的孔隙率、孔径、生物力学强度等性能均符合骨替代材料的要求。

Objective To explore a new bone substitute for bone grafting and evaluate its properties.Methods Demineralized bone matrix, polylactic acid and NaCI that were proportionally mixed was performed to obtain the bone grafting material, and its properties as poroshy, pore size and mechanical strength were compared with those of the material prepared by solvent cast-particle leaching. Result Compared with those of the material made by solvent cast - particle leaching, the mecheanical strength of the new composited artificial bone material was 12-fold stonger with an average porosity rate of 55.20%, pore size of 227.33μm, compressive strength of 5.52MPa and ftexural strength of 19.61MPa. Conclusion The new technique adopted in this study can effectively enhance the biomechanics of the composited artificial bone material, which can be suitable for repairing bone defect.